Hubungan antara Perubahan Kadar Hormon Progesteron dan Jumlah Fibroblas Gingiva pada Kehamilan (Kajian pada Tikus Sprague dawley)
Pregnancy causes alterations in oral cavity which are influenced by estrogen and progesteron hormones. Progesteron and estrogen influence soft tissue in oral cavity especially on local irritation caused by decreased ability of gingiva to deal with inflammation. The amount of gingival fibroblast cell...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/124870/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=65031 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Pregnancy causes alterations in oral cavity which are influenced by
estrogen and progesteron hormones. Progesteron and estrogen influence soft
tissue in oral cavity especially on local irritation caused by decreased ability of
gingiva to deal with inflammation. The amount of gingival fibroblast cellular
proliferation was also influenced by progesterone hormone. Aim of this research
is to know the correlation between progesteron hormone level with the amount of
gingival fibroblast in pregnancy period (studies in Sprague dawley).
This research used 12 blood samples and gingiva speciments which were
taken from Sprague dawley mice, consisted of 3 pregnant Sprague dawley mice at
their 10th day of pregnancy, 3 pregnant Sprague dawley mice at their 14th day of
pregnancy, 3 pregnant Sprague dawley mice at their 17thday of pregnancy and 3
unpregnant Sprague dawley mice. Blood samples were taken from orbita
foraments of Sprague dawley mice to then be tested and analysed so progesterone
hormone level can be measured using ELISA, while to count the amount of
gingival fibroblasts in gingiva, tissue samples were taken from labial gingiva
under two anterior teeth of mandibular with punch biopsy technique. Speciments
then were made and be stained by hematoxylin eosin. The result was statistically
analyzed by Pearson correlation test.
Result of this research shows a significant correlation (p<0,05) with
negative direction between the alteration of progesteron hormone level and the
amount of gingiva fibroblast, with correlation coefficient -0,949. Conclusion of
this research is the higher level of progesterone hormone in pregnancy, the lower
amount of gingiva fibroblast cells (studies in Sprague dawley). |
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