STUDI PELEPASAN IN VITRO KURKUMIN DARI FILM KALSIUM ALGINAT DENGAN PENAMBAHAN EMULSIFIER TWEEN-80 DAN SPAN-80
The controlled release of curcumin from calcium alginate (Ca-Alg) films that emulsified using Tween-80 and Span-80 had been studied. This research provides an important insight into the effect of hydrophilicity and lipophilicity of the emulsifiers on the release rates of the curcumin from Ca-Alg fil...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/125021/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=65186 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | The controlled release of curcumin from calcium alginate (Ca-Alg) films
that emulsified using Tween-80 and Span-80 had been studied. This research
provides an important insight into the effect of hydrophilicity and lipophilicity of
the emulsifiers on the release rates of the curcumin from Ca-Alg films.
Curcumin-loaded alginate films, which contained different ratio of
emulsifiers compositions, have been prepared using calcium chloride (CaCl2) as
the cross-linking agent. The films were characterized using Spectrometer IR and
SEM (Scanning Electron Microscopy). In vitro controlled release rate study of the
curcumin from the films were investigated for 8 hours. Hydrophile-Lipophile
Balance (HLB) value of emulsifier Tween-80 and Span 80 was varied in the range
of 11,9 to 14,0. The concentration of curcumin that released from the films at
various time intervals was determined UV-Vis Spectrophotometrically.
IR Spectrometry of Ca-Alg/kurkumin/emulsifier film characterization
showed absorption bands at 3448 cm
-1
(hydroxyl groups), 1627 cm
-1
(carbonyl
groups) of the alginate, 2924 and 2862 cm
-1
(C�H sp
3
groups of the emulsifier).
The result of SEM indicated that the microstructure of the film surface could vary
with the concentration of Tween-80 and Span-80. Films for higher concentration
of Tween-80 showed rougher surface, but films for higher concentration of Span80
were more compact. Experiment on the release of curcumin showed that the
relative amount of curcumin released within 8 hours increased from 17.7% to
64.4% when the film composition was varied from alginate:Tween-80:Span-80=
74:19:7wt% to 54:41:5wt%. The pharmacokinetics model showed that the
curcumin release from the alginate film followed Korsmeyer-Peppas equation.
This result indicated that the release mechanism was mainly by diffusion process. |
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