perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow)
Tubal ligation is a gynaecological surgery performed often which includes as an outpatient surgery. The anesthesia technique that can be used in this procedure is the total intravenous anesthesia (TIVA) using diazepam and ketamine. Post-operative nausea and vomiting (PONV) is a complication that occ...
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[Yogyakarta] : Universitas Gadjah Mada
2013
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id-ugm-repo.1258742016-03-04T08:44:58Z https://repository.ugm.ac.id/125874/ perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) , dr. Adam Kurnia Wandana , DR. Med. Dr. Untung Widodo, SpAn, KIC. ETD Tubal ligation is a gynaecological surgery performed often which includes as an outpatient surgery. The anesthesia technique that can be used in this procedure is the total intravenous anesthesia (TIVA) using diazepam and ketamine. Post-operative nausea and vomiting (PONV) is a complication that occurs often in tubal ligation which delays patient discharge, causes discomfort and increases the risk of aspiration. Ondansetron and dimenhydrinate could be used as antiemetic prophylaxis. This study compares the efficacy of oral premedication dimenhydrinate against ondansetron in reducing PONV after tubal ligation procedure. This is a double blinded randomized clinical trial of 110 patients with physical status of ASA I and II with the TIVA technique using diazepam and ketamine. The patients were randomly assigned to 2 groups. Group D received dimenhydrinate 50 mg per oral and Group O received Ondansetron 4 mg per oral. The incidence of postoperative nausea and vomiting was statistically analysed using the Chi square test, whereby p<0.05 showed statistical significance. Demographic data such as age, body weight, blood pressure and duration of operation were tested using the independent t test. The incidence of PONV in the dimenhydrinate 50 mg per oral group were 15 patients (27.3%) lower than the ondansetron 4 mg per oral with 28 patients (50.9%) and this difference is statistically significant (p=0.011). In the dimenhydrinate group, 40 patients (72.7%) were free of PONV, 9 patients (16.4%) experienced nausea only, and 6 patients (10.9%) experienced vomiting/retching, while in the ondansetron group, 27 patients (49.1%) were free of PONV, 18 patients (32.7%) experienced nausea only and 10 patients (18.2%) experienced vomiting/retching and this difference between the two groups of study is statistically significant (p=0.038). Oral premedication of 50mg dimenhydrinate is more efficacious than ondansetron 4mg in reducing the incidence of PONV in tubectomy operations using the TIVA anesthesia technique using ketamine 1mg/kgBB and diazepam 0.1 mg/kgBB. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , dr. Adam Kurnia Wandana and , DR. Med. Dr. Untung Widodo, SpAn, KIC. (2013) perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow). UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=66055 |
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ETD , dr. Adam Kurnia Wandana , DR. Med. Dr. Untung Widodo, SpAn, KIC. perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
description |
Tubal ligation is a gynaecological surgery performed often which includes as an
outpatient surgery. The anesthesia technique that can be used in this procedure is the
total intravenous anesthesia (TIVA) using diazepam and ketamine. Post-operative
nausea and vomiting (PONV) is a complication that occurs often in tubal ligation which
delays patient discharge, causes discomfort and increases the risk of aspiration.
Ondansetron and dimenhydrinate could be used as antiemetic prophylaxis. This study
compares the efficacy of oral premedication dimenhydrinate against ondansetron in
reducing PONV after tubal ligation procedure.
This is a double blinded randomized clinical trial of 110 patients with physical
status of ASA I and II with the TIVA technique using diazepam and ketamine. The
patients were randomly assigned to 2 groups. Group D received dimenhydrinate 50 mg
per oral and Group O received Ondansetron 4 mg per oral. The incidence of postoperative
nausea and vomiting was statistically analysed using the Chi square test,
whereby p<0.05 showed statistical significance.
Demographic data such as age, body weight, blood pressure and duration of operation
were tested using the independent t test.
The incidence of PONV in the dimenhydrinate 50 mg per oral group were 15
patients (27.3%) lower than the ondansetron 4 mg per oral with 28 patients (50.9%) and
this difference is statistically significant (p=0.011). In the dimenhydrinate group, 40
patients (72.7%) were free of PONV, 9 patients (16.4%) experienced nausea only, and 6
patients (10.9%) experienced vomiting/retching, while in the ondansetron group, 27
patients (49.1%) were free of PONV, 18 patients (32.7%) experienced nausea only and
10 patients (18.2%) experienced vomiting/retching and this difference between the two
groups of study is statistically significant (p=0.038).
Oral premedication of 50mg dimenhydrinate is more efficacious than
ondansetron 4mg in reducing the incidence of PONV in tubectomy operations using the
TIVA anesthesia technique using ketamine 1mg/kgBB and diazepam 0.1 mg/kgBB. |
format |
Theses and Dissertations NonPeerReviewed |
author |
, dr. Adam Kurnia Wandana , DR. Med. Dr. Untung Widodo, SpAn, KIC. |
author_facet |
, dr. Adam Kurnia Wandana , DR. Med. Dr. Untung Widodo, SpAn, KIC. |
author_sort |
, dr. Adam Kurnia Wandana |
title |
perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
title_short |
perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
title_full |
perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
title_fullStr |
perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
title_full_unstemmed |
perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
title_sort |
perbandingan efektivitas premedikasi oral ondansetron 4 mg dan dimenhidrinat 50 mg untuk mengurangi mual dan muntah pasca tindakan metode operasi wanita (mow) |
publisher |
[Yogyakarta] : Universitas Gadjah Mada |
publishDate |
2013 |
url |
https://repository.ugm.ac.id/125874/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=66055 |
_version_ |
1681232337683087360 |