FABRIKASI SCAFFOLD BERPORI HIDROKSIAPATIT DENGAN POLIMER HIDROKSI ETIL SELULOSA DAN POLI VINIL ALKOHOL

• Main Authors: , AMALINA ISYATURRODLIYAH, , Drs. Roto, M.Eng, Ph.D.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/126459/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=66682
• Institution: Universitas Gadjah Mada

Fabrication of hydroxyapatite (HAP) scaffold was carried out by adding HAP with hydroxy ethyl cellulose (HEC) and poly vinyl alcohol (PVA). HAP was synthesized via precipitation method using CaCl2 dan (NH4)2HPO4 as precursors. Porous scaffold was obtained by utilizing HEC as porogen and PVA as binder which will be removed by calcination at 500 ºC followed by sintering at 1230 ºC. The objective is to study the effect of binder and porogen to the morphology, porosity and mechanical strength of scaffold at predertemined ratio of HAP and HEC (w/w) and PVA percentage (% w/v). Mechanical strength, porosity and scaffold morphology were characterized by using Material Testing Machine, liquid displacement method and Scanning Electron Microscopy (SEM). The results show that the addition of PVA can improve the mechanical strength of HAP scaffold. The highest mechanical strength was obtained from the 15% PVA composite. Increasing HEC content also led to increasing the porosity. The highest scaffold porosity was achieved at 9:2 HAP to HEC ratio. The fabricated scaffold HAP gave compressive strength ranging from 6.10 to 33.1 MPa and its porosity 50.35 to 79.74%. The 9:2 10% scaffold was found to have 79.74% porosity, mechanical strength of 7.00 MPa, interconnected pores and resistant to cracking. The physical properties of this scaffold are found to have similarities to that human cancellous bone.