HUBUNGAN ANTARA TUMOR ASSOCIATED MACROPHAGES (TAMs) DENGAN INVASI TUMOR LIMFOVASKULAR PADA KARSINOMA PAYUDARA
Background : Invasive ductal carcinoma (NOS) is the most common histological type of breast carcinoma. The most important factor in determining prognostic of breast carcinoma is lymphnode metastasis which is initiated with tumor lymph vessel invasion. In carcinoma, inflammatory cell infiltration is...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/127809/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68099 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background : Invasive ductal carcinoma (NOS) is the
most common histological type of breast carcinoma. The
most important factor in determining prognostic of breast
carcinoma is lymphnode metastasis which is initiated with
tumor lymph vessel invasion. In carcinoma, inflammatory
cell infiltration is dominated by macrophages, Tumor
Associated Macrophages (TAMs). TAMs have important role
in breast carcinoma progresivity by secreting
inflammatory mediators that can induce angiogenesis,
proliferation, invasion, and metastasis. In breast
carcinoma TAMs density has been shown to correlate with
poor prognosis. Role of TAMs in the occurence of LVI in
breast carcinoma is still unclear.
Objectives : To know the correlation between Tumor
Associated Macrophage (TAMs) with LVI in breast
carcinoma.
Methods : 44 of blocks paraffin of invasive ductal
carcinoma of the breast in RSUP Dr. Sardjito, Yogyakarta.
These spesimens were stained immunohistochemically with
monoclonal antibody anti CD68 and D2-40. Expression of
TAMs were determined from the amount of macrophages which
cytoplasm expressed CD68. LVI was determined by present
or absent of tumor cell invasion to lymph vessel which
the endotel cell expressed D2-40. Five microscope fields
were used and cut-off point of TAMs was determined from
median value. Correlation between amount of TAMs with LVI
were analized with Pearson Chi-square Test correlation.
Results : Cut-off point of TAMs was 49. Frequency
of high TAMs : 22 (50%), low : 22 (50%). Number of sampel
contain of LVI : 38 (86,4%), and absent : 6 (13,6%).
There were significant correlation between TAMs
infiltration with LVI in breast carcinoma p=0,008 CI 95%
(1,065-1,776).
Conclusion : This study supported the important role
of TAMs in tumor lymphovascular invasion in breast
carcinoma. |
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