UJI POTENSI DAYA ANTIBAKTERI SENYAWA FENANTROLIN 1 TERHADAP ISOLAT KLINIS BAKTERI SALMONELLA TYPHI SECARA IN VITRO
Background: Salmonella typhi is one of the most common causes of gastrointestinal infections in Indonesia. Improper use of antibiotics contributes to the rise of resistance problems in the treatment of Salmonella typhi infection. The development of new antibiotics is needed as part of efforts to tac...
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Main Authors: | , |
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Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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Subjects: | |
Online Access: | https://repository.ugm.ac.id/128011/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68336 |
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Institution: | Universitas Gadjah Mada |
Summary: | Background: Salmonella typhi is one of the most common
causes of gastrointestinal infections in Indonesia.
Improper use of antibiotics contributes to the rise of
resistance problems in the treatment of Salmonella
typhi infection. The development of new antibiotics is
needed as part of efforts to tackle the problem of
bacterial resistance against the existing antibiotics.
Phenanthroline 1 is a new compound that is synthesized
from 1,10-phenanthroline compound. Based on previous
studies, 1,10-phenantroline has quality as an
antibacterial compound.
Objective: To determine the potency of a new
antibacterial compound derived from 1,10-Phenanthroline
(Phenanthroline 1) against clinical isolates of
Salmonella typhi by establishing the value of the
Minimum Inhibitory Concentration (MIC) and Minimum
Bactericidal Concentration (MBC).
Method: Descriptive experimental design is used in this
study and Macrobroth Dilution method is chosen to
determine the antibacterial potency of Phenanthroline 1
compound against Salmonella typhi.
Result: Based on the experiments, Phenanthroline 1 has
the Minimum Inhibitory concentration (MIC) at 100 μg/ml
and Minimum Bactericidal Concentration (MBC) at 200
μg/ml against clinical isolates of Salmonella typhi.
Conclusion: Phenanthroline 1 compound is, at a certain
concentration, capable of inhibiting and killing
clinical isolates of Salmonella typhi in in vitro
environment. |
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