OPTIMASI FORMULA SIRUP EKSTRAK ETANOLIK DAUN KEMBANG SEPATU (Hibiscus rosa-sinensis L.) DENGAN BAHAN TAMBAHAN GLISERIN, SIRUPUS SIMPLEX, DAN CMC-NA

• Main Authors: , Yohanes Juliantoni, , Dr. rer. nat. Triana Hertiani, Apt.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/128069/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68398
• Institution: Universitas Gadjah Mada

Leaf of Hibiscus (Hibiscus rosa-sinensis L.) is traditionally used for relieving cough, asthma disorders, and bronchitis. In order to improve the aesthetics and acceptability, the extract should be formulated in syrup dosage form. Consider that the extract has a bitter taste and is poorly soluble in water, the composition of sweeteners, thickeners , stabilizers , and kosolven should be optimized. This study was aimed to optimize the syrup dosage form formula of Hibiscus leaf extract (Hibiscus rosa-sinensis L.)based on physical properties using the Simplex Lattice Design. Dry pulverized samples was delipidated by using petroleum ether. The residue was macerated by using 70% ethanol and then evaporated. Syrup were made in 7 different formulas and were checked for the physical properties, including viscosity, pour ability, acidity, and taste response. The data was evaluated with Design Expert ® software to determine the optimum formula. One sample t-test was conducted to determine the differences between the predictions of the physical properties of the optimum formula with the experimental results. Mucolytic effect of the optimum formula was tested in vitro. Stability of the optimum was evaluated through weekly comparison of physical properties, starting at day 0 and ended after 1 month of storage. Optimum formula was determined in a proportion of 16.85% glycerin