THE DIFFERENCE OF ALKALINE PHOSPHATASE, BILIRUBIN,AND GAMMA GLUTAMYL TRANSFERASE LEVEL IN DIFFERENT GALLSTONE LOCATION OF GALLSTONE PATIENT IN RSUP DR SARDJITO.

• Main Authors: , SARAH MARDHIAH BINTI SUDIN, , dr. Catharina Triwikatmani, M.Kes, SpPD
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/128114/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68445
• Institution: Universitas Gadjah Mada

Background : In daily practice, it is difficult to differentiate between cholelithiasis and choledocholithiasis patients by clinical symptoms. Even though obstructive jaundice usually happen in choledocholithiasis, but it can also being absence. This problem can lead to underdiagnosis and cause the stone to be remain in the bile duct even after operation. The biochemical testing such as bilirubin, alkaline phosphatase and gamma glutamyl transferase can indicate biliary obstruction. Aim : The aim is to evaluate the difference in biochemical marker which are bilirubin, alkaline phosphatase and gamma glutamyl transferase at different gallstone locations in cholelithiasis and choledocholithiasis patients. Method : 88 patients from surgery department are selected for this research. The subjects are divided into two groups which are patients with choledocholithiasis (n=11) and cholelithiasis (n=77). For total bilirubin, 75 cholelithiasis and 11 choledocholithiasis are selected. While 28 cholelithiasis and 7 choledocholithiasis patients for difference in alkaline phosphatase and 18 cholelithiasis and 7 choledocholithiasis patients for difference in Gamma Glutamyl Transferase. The liver marker level were taken maximum one week before the operation. Results : Significant different was found in Bilirubin and ALP P < 0.05 . Overall, the median shows that the level of Bilirubin and ALP is higher in choledocholithiasis if compared with cholelithiasis patients. While no significant different in Gamma Glutamyl Transferase was found P > 0.05. Eventhough overall median results shows that the level of GGT in choledocholithiasis is higher than in cholelithiasis but some low ranks and some high ranks will occur in each group, that is the ranks will be distributed across the two group which are cholelithiasis and choledocholithiasis more or less evenly. Conclusion : In a conclusion, only bilirubin and alkaline phosphatase level have a significant difference in different gallstone location.