PREDISPOSING FACTOR OF MULTIDRUG-RESISTANT TUBERCULOSIS IN SARDJITO GENERAL HOSPITAL, YOGYAKARTA FROM 2009 TO 2012
Background: Tuberculosis (TB) is a growing global health problem, with increasing evidence of multidrug-resistant (MDR)-TB. By the year of 2012, out of the 8.6 million prevalent TB cases, around 450,000 were estimated to be multidrug-resistant. It is a serious threat to the goal achievement of the S...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/128221/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=68557 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: Tuberculosis (TB) is a growing global health
problem, with increasing evidence of multidrug-resistant
(MDR)-TB. By the year of 2012, out of the 8.6 million
prevalent TB cases, around 450,000 were estimated to be
multidrug-resistant. It is a serious threat to the goal
achievement of the Stop TB partnership to eliminate TB as a
public health problem by 2050, due to the complexities in
diagnosis and treatment, and also the high treatment
failure and mortality rates. Indonesia, with a population
of around 230 million, carries the third highest TB burden
globally. Indonesia also ranks 9th out of 27 countries with
high burden MDR-TB. To our knowledge, for the past decade,
there have been no data on these aspects of TB patients in
Sardjito General Hospital Yogyakarta, and even in
Yogyakarta. Therefore, we plan to establish a sufficient TB
patient database to reveal the predisposing factor and
prevalence of MDR-TB patients. This record will provide
ample opportunity as a starting point of the future
studies.
Objective: The general objective of this study is to
further observe and analyze the predisposing factor of MDRTB
patients, especially those related with demographic
feature and clinical information of the patients.
Method: This study used a retrospective cohort method to
determine correlation between the demographic feature and
clinical information of TB patients who received treatment
in Sardjito General Hospital between year of 2009 to 2012,
and the development to MDR-TB. The data were obtained from
the medical record.
Result: From the 249 subjects, 13 (5,2%) patients
considered as MDR-TB and 236 patients as sensitive TB.
Patients with MDR-TB were slightly older and less likely to
be male compared to sensitive TB patients. From the
univariate analysis, previous treatment, DM, and organ
involvement were considered significantly related to MDR-TB
development with p value of <0,001, 0,021, and 0,017,
respectively. In bivariate analysis, only DM considered as
predisposing factor of MDR-TB (P= 0,038 |
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