PERBEDAAN EKSPRESI RESEPTOR PROGESTERON PADA BERBAGAI USIA DAN JENIS KELAMIN PASIEN MENINGIOMA ORBITOKRANIAL JINAK

• Main Authors: , BETHARI KUNTI ABIANTI, , dr. Agus Supartoto, Sp.M(K).
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/128727/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=69093
• Institution: Universitas Gadjah Mada

Background: Menignioma is a slow-growing benign brain tumors. The etiology of meningioma is still unknown, however gender-spesific hormones especially Progesterone Receptor (PR) is believed to have a role in the pathogenesis of this tumor. PR in meningioma influences tumor�s prediction and progression. The role of PR in benign meningioma based on age and gender is still unclear. Objective: This study aims to seek for differences between PR�s expression in meningioma with variation of age and gender. Methods: This study was a descriptive comparative study conducted retrospectively with the paraffin block of all meningioma patients from year 2011-2012 that were available at the Anatomical Pathology Laboratory Dr. Sardjito�s hospital as subject. The samples were sliced then examined by immunohistochemistry�s technic to detect progesterone receptors expression. The average age�s difference with PR expression in benign meningioma was analyzed with Independent t test. The different proportion of gender with PR�s expression was analyzed with Fisher test. Results: The study did not find any significant difference of average age and PR�s expression, however there were significant differences of gender proportion with PR�s expression. The study shows that 50% of meningiomas expressed progesterone reseptors with the proportion of female patients (58,3%) higher than male patients. Conclusion: In this study, there was no significant difference between PR�s expression and average ages but there was significant difference with gender in beningn orbitocranial meningiomas.