INFILTRASI SEL LEKOSIT POLIMORFONUKLEAR DAN MAKROFAG PADA PROSES PENYEMBUHAN LUKA PASCA EKSTRAKSI GIGI MARMUT (Cavia cobaya) SETELAH APLIKASI GEL EKSTRAK TERIPANG (sTICHOPUS NOCTIVAGUS) 75%
Tooth extraction causes wound formation at the site of extraction. Wound healing process consists of inflammation, proliferation and tissue remodeling phase. Sea cucumber (Stichopus noctivagus) contains flavonoid and saponin which act as an anti-inflammation and antibacterial in the healing process....
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/130095/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=70507 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Tooth extraction causes wound formation at the site of extraction. Wound
healing process consists of inflammation, proliferation and tissue remodeling phase.
Sea cucumber (Stichopus noctivagus) contains flavonoid and saponin which act as an
anti-inflammation and antibacterial in the healing process. This study aimed to
determine the effect of 75% sea cucumber extract gel towards the infiltrations of
polymorphonuclear leucocyte and macrophage cells.
This study involved 16 guinea pigs (cavia cobaya) aged 3-4 months old. The
subjects were randomly divided into 2 groups namely treatment and control groups.
Tooth extraction was performed on the lower left incisors. Twenty microliter 75%
percent sea cucumber extract gel was applied into the socket of the treatment group,
while 2% carboxymethyl cellulose was applied into the socket of the control group.
The guinea pigs were then decapitated on 1, 3, 7, and 14 days after the treatment.
The specimens were embedded in paraffin, sectioned serially, and stained using
hematoxylin eosin. Polymorphonuclear leucocytes and macrophages were observed
under microscope.
ANOVA showed significant differences (p<0.05) among the groups, indicating
that 75% sea cucumber extract gel affected PMN leucocyte and macrophage
infiltration. The number of PMN leucocyte and macrophage infiltration of the
treatment group was significantly (p<0.05)less than the control group in all
observation periods.
In conclusion, application of 75% sea cucumber extract gel into post
extraction socket wound reduce the number of PMN leucocyte and macrophage
infiltration in the post extraction wound healing process.
Keywords: post extraction wound healing, polymorfonuclear leucocyte, macrophage,
sea cucumber extract gel |
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