EFEK SEDIAAN HERBAL KALKUGAMA TERHADAP KALSIUM URIN DAN HISTOPATOLOGI GINJAL TIKUS UROLITIASIS KARENA INDUKSI ETILEN GLIKOL
The treatment of kidney stone (renal calculi) with surgery, endoscopy, or ultrasonic waves are relatively expensive, hence usage of drugs that could prevent and dissolve kidney stone is more preferred. Herbs that have anticalculi potential include Sonhus arvensis L., Sericocalyx crispus (L.) Bremek,...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/130178/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=70593 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | The treatment of kidney stone (renal calculi) with surgery,
endoscopy, or ultrasonic waves are relatively expensive, hence usage of
drugs that could prevent and dissolve kidney stone is more preferred. Herbs
that have anticalculi potential include Sonhus arvensis L., Sericocalyx
crispus (L.) Bremek, and Orthosiphon aristatus which used as basic
ingredients of Kalkugama. This study aims to prove anticalculi activity of
Kalkugama preparation.
Study was carried out on male Wistar rats, calculi forming was
induced by administration of 0,75% ethylene glycol and 0,75% ammonium
chloride. Preventive agent (AP) and curative agent (AK) group received 176
mg/kgBW of Kalkugama suspensions, AP from day 1 to 14th while AK
from day 15 to 21th. At the end of the study, 24-hour urine of each rat was
collected. Urinary volume, pH, and calcium level were measured. Blood
was also sampled from each rat, then creatinine and uric acid levels in serum
were measured. Kidney from each rat was taken for histopathology test. The
results were analyzed statistically with ANOVA and Mann Whitney.
The results of this study showed that administration of Kalkugama
as a preventive agent can decrease urinary calcium level significantly
(P<0.05) while administration of Kalkugama as a curative agent tend to
increasing urinary calcium level (Sig.>0,05). Hence, according to urinary
calcium level Kalkugama can prevent and cure the renal calculi on test rats.
In addition, Kalkugama could also reduce the severity of interstitial
nephritis in histopathology test of sample kidneys.
Keywords: Kalkugama, anticalculi, ethylene glycol |
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