EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK LARUT ETANOL DAUN MIMBA (Azadirachta indica A. Juss.) DAN DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr. TERSTANDAR RUTIN DAN KUERSETIN PADA TIKUS DIABETES TERINDUKSI ALOKSAN
Diabetes mellitus is a worldwide major health problem. WHO estimated that more than 220 million people worldwide have diabetes and this number is likely to double by 2030. Exploration of plant combinations could be an alternative for diabetes treatment. Azadirachta indica A. Juss. and Gynura procumb...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/130926/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=71359 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Diabetes mellitus is a worldwide major health problem. WHO estimated
that more than 220 million people worldwide have diabetes and this number is
likely to double by 2030. Exploration of plant combinations could be an
alternative for diabetes treatment. Azadirachta indica A. Juss. and Gynura
procumbens (Lour.) Merr. are reported to have antidiabetes properties. The aim of
this study is to evaluate the hypoglycemic effect of combination of A. indica and
G. procumbens ethanolic extract in alloxan-induced diabetic rats.
Both plants were macerated with ethanol 70%. Determination of rutin in
A. indica and quercetin in G. procumbens was performed by TLC-densitometry.
Hyperglycemia in rats was induced by alloxan 150 mg/kgBW. The rats were
treated with 3 types of combinations for 15 days. Hypoglycemic effect was
evaluated by estimating the blood glucose levels and the rats pancreas
histopathology study.
A. indica contains 2,86±0,15% rutin and G. procumbens contains
18,86±0,86% quercetin. Combination at the ratio of 50mg/kgBW
A.indica:112,5mg/kgBW G.procumbens showed the highest hypoglycemic effect:
68,7412±4,8317% (preprandial) and 73,9072±3,1822% (postprandial).
Histopathology studies indicated that this combination improved the morfology
and ultrastructure changes of the islets and β cells. It also increased insulin
productions and decreased the elevated glucose concentrations. It can be
concluded that its hypoglycemic effect was better than that of single treatment of
A. indica or G. procumbens. That combination is also potential to be developed as
a blood glucose-lowering agent for diabetic patients. |
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