Pengaruh Aplikasi Simvastatin Terhadap Jumlah Osteoblas Tulang Alveolar dalam Proses Penyembuhan Periodontitis, kajian pada Sprague dawley
Periodontitis is an inflammatory disease that causes damage to the alveolar bone and the major cause of tooth loss. Simvastatin, a cholesterol-lowering drug, has been shown to help the process of new bone formation. One of the important indicator of bone regeneration is the formation of osteoblasts....
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Main Authors: | , |
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Format: | Theses and Dissertations NonPeerReviewed |
Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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Subjects: | |
Online Access: | https://repository.ugm.ac.id/131748/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=72251 |
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Institution: | Universitas Gadjah Mada |
Summary: | Periodontitis is an inflammatory disease that causes damage to the alveolar
bone and the major cause of tooth loss. Simvastatin, a cholesterol-lowering drug,
has been shown to help the process of new bone formation. One of the important
indicator of bone regeneration is the formation of osteoblasts. The purpose of this
study was to determine the effect of topical application of simvastatin on the
number of osteoblasts in alveolar bone formation after ligature-induced
periodontitis in rats.
Twenty-four Sprague dawley rats, male, aged 2.5-3 months, weighed 180-
220 grams, were divided into two groups. The treatment group was topically
applied simvastatin gel after ligation induced periodontitis for seven days while
control group applied CMC-Na 1%. Three subject from each group were
sacrificed after 3, 5, 7, and 14 days. The augmented part and surrounding tissues
were cut, decalcified, and stained with Hematoxylin-Eosin staining.
The results showed the mean number of osteoblasts in simvastatin
treatment group was higher (55.58 ± 25.25) compared to the control group (35.41
± 18.26). However, the results of the ANOVA test showed no significant
differences between groups (p> 0.05).
Based on these results it can be concluded that there was no significant
difference in the number of osteoblast between simvastatin treatment group and
control group. |
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