PENENTUAN pKaIBUPROFEN DAN EFEK PEMBENTUKAN KOMPLEKSIBUPROFEN DENGAN BETA-SIKLODEKSTRIN TERHADAP KELARUTAN IBUPROFEN

• Main Authors: , ARIYANTI, , Prof. Dr. Suwaldi M., M.Sc.,Apt
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/132014/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=72530
• Institution: Universitas Gadjah Mada

Ibuprofen is a nonsteroid anti-inflammatory drug (NSAID) that can inhibit activities of siklooksigenase-1 and siklooksigenase-2 isoenzyme, so thats with inhibiting the changing of arachidonic acid to prostaglandin can be decreased. Ibuprofen belongs to BCS class II, because it has high permeability and low solubility. The goals of this research are to determine the pKa of ibuprofen and to know the influence of the complexe formation of ibuprofen with β-cyclodextrin on ibuprofen solubility. Determinnation of the pKa value of ibuprofen has been conducted by measuring absorbance at wavelength 266 nm. The optimization of complexes formation has been worked using factorial design method. Than, the complexes of ibuprofen and β-cyclodextrin evaluated using infrared spectrophotometry, and optimized with using software design expert version: 7.1.3. The result of this research showeds that the pKa value of ibuprofen wasis 4, 37 ± 0,07 and 5, 24 ± 0,07. The complexes ibuprofen with β--siklodekstrin was evaluated using infrared spectrophotometry there was no peak at 1721 cm-1 that indicated that there was no functional group of �C=O. Based on simplex lattice design calculation, the best complexes consisted of ibuprofen and β-cyclodextrin in ratio120 and 180. The solubilitydata showed that complexes of ibuprofen with β-cyclodextrin was2,30 ± 0,12 timesat pH 1,30 ± 0,16 times