OPTIMASI FORMULA TABLET HISAP ASAM MEFENAMAT MENGGUNAKAN KOMBINASI ZAT PENGIKAT AMILUM-PGA (Pulvis Gummi Arabica)-SUKROSA BERDASARKAN METODE SIMPLEX LATTICE DESIGN
Mefenamic acid is indicated as an anti-inflammatory drug that administered orally in tablet and capsule dosage form. But for some patients with inabilities to swallow, it is inconvenience and give a bitter taste. Mefenamic acid troches is the solution for this problem. This research aims to identifi...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2014
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/132476/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=73011 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Mefenamic acid is indicated as an anti-inflammatory drug that
administered orally in tablet and capsule dosage form. But for some patients with
inabilities to swallow, it is inconvenience and give a bitter taste. Mefenamic acid
troches is the solution for this problem. This research aims to identified the effect
of starch, PGA (Pulvis Gummi Arabica) and sucrose as binding agents on physical
properties of mefenamic acid troches.
Seven combinations of starch : PGA : sucrose were made, which are FI
(100%:0%:0%), FII (0%:100%:0%), FIII (0%:0%):100%, FIV (50%:50%:0%),
FV (0%:50%:50%), FVI (50%:0%:50%, and FVII (33,3%:33,3%:33,3%). Wet
granulation was method was chosen to produce the troches. The evaluation of
physical properties of mefenamic acid troches on this research includes weight
uniformity test, hardness test, friability test, late time test, and responsive taste
test. The data then analyzed with Simplex Lattice Design method with Design
Expert version 7.1.5.
The results showed that PGA (Pulvis Gummi Arabica) would increase the
hardness of the mefenamic acid troches. The mixing of the three binding agents
would decrease the value of the troches� friability and give a good taste for the
troches and the starch could accelerate the late time of mefenamic acid troches.
The combination of starch : PGA (Pulvis Gummi Arabica) : sucrose with the ratio
50% : 50% : 0% were placed in optimum area with the highest desirability value
that gave optimum physical properties of mefenamic acid. |
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