SINTESIS Zn-Al-AMOKSISILIN HIDROTALSIT MELALUI PENUKARAN ANION

• Main Authors: , ARIFAH SUKASRI, , Dr. Roto, M.Eng.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2014
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/133922/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=74831
• Institution: Universitas Gadjah Mada

Synthesis of Zn-Al-amoxicillin hydrotalcite by anion exchange has been studied. The aim of this research was to synthesize and characterize Zn-Alamoxicillin hydrotalcite by anion exchange. Kinetics, capacity of anion exchange and regeneration process of Zn-Al-amoxicillin hydrotalcite were studied. The Zn- Al-NO3 hydrotalcite was first synthesized by coprecipitation method followed by hydrothermal treatment at 100 °C for 15 h. The nitrate was later exchanged with amoxicillin to yield Zn-Al-amoxicillin hydrotalcite. The Zn-Al-amoxicillin hydrotalcite was characterized using XRD and FTIR. Characterization using XRD showed that the basal spacing d003 of Zn-Alamoxicillin was 12.74 �. The FTIR spectra suggested that vibration of COOgroup was observed at 1458 cm-1 and 1520 cm-1, C-N and δ N-H at 1258 cm-1, and C-O at 1111 cm-1 and 1034 cm -1. The optimum condition for anion exchange was obtained at contact time 120 min and anion exchange capacity 100.7 meq/100 g hydrotalcite. The results showed that anion exchange reaction followed second order with reaction rate constant k of 2x10-3 s-1. Regeneration process of Zn-Alamoxicillin hydrotalcite with NO3 - could be done but not complete.