ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN

ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN

Andrographis paniculata containing an active compound andrographolide, and Curcuma xanthorrhiza containing curcumin, were reported to have potent hypoglycemic activity. The aim of this study is to evaluate the antidiabetic effects of the combination of andrographolide and curcumin in insulin resi...

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Main Authors: , Indah Solihah, , Prof. Dr. Suwidjiyo Pramono, DEA., Apt.
Format: Theses and Dissertations NonPeerReviewed
Published: [Yogyakarta] : Universitas Gadjah Mada 2014
Subjects:
ETD
Online Access:https://repository.ugm.ac.id/134260/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=75328
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spelling id-ugm-repo.1342602016-03-04T07:57:38Z https://repository.ugm.ac.id/134260/ ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN , Indah Solihah , Prof. Dr. Suwidjiyo Pramono, DEA., Apt. ETD Andrographis paniculata containing an active compound andrographolide, and Curcuma xanthorrhiza containing curcumin, were reported to have potent hypoglycemic activity. The aim of this study is to evaluate the antidiabetic effects of the combination of andrographolide and curcumin in insulin resistance rats. Andrographolide was isolated using gradual fractionation method. Qualitative analysis of andrographolide used 2-dimensional TLC, whereas quantitative analysis used HPLC. Insulin resistance in rat was induced by oral administration of fructose 1.8 g/kgBW, 2 mL duck egg yolks, and 2 mL lard oil for 120 consecutive days. Insulin resistance in rat was confirmed by using hypoglycemic activity of glibenclamide on day 120. On the day of 120-134, rats were administered with i.e, metformin 45 mg/kgBW as a positive control, andrographolide 4.5 mg/kgBW, curcumin 45 mg/kgBW, combination andrographolide:curcumin 1:3 [Yogyakarta] : Universitas Gadjah Mada 2014 Thesis NonPeerReviewed , Indah Solihah and , Prof. Dr. Suwidjiyo Pramono, DEA., Apt. (2014) ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=75328
institution Universitas Gadjah Mada
building UGM Library
country Indonesia
collection Repository Civitas UGM
topic ETD
spellingShingle ETD
, Indah Solihah
, Prof. Dr. Suwidjiyo Pramono, DEA., Apt.
ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN
description Andrographis paniculata containing an active compound andrographolide, and Curcuma xanthorrhiza containing curcumin, were reported to have potent hypoglycemic activity. The aim of this study is to evaluate the antidiabetic effects of the combination of andrographolide and curcumin in insulin resistance rats. Andrographolide was isolated using gradual fractionation method. Qualitative analysis of andrographolide used 2-dimensional TLC, whereas quantitative analysis used HPLC. Insulin resistance in rat was induced by oral administration of fructose 1.8 g/kgBW, 2 mL duck egg yolks, and 2 mL lard oil for 120 consecutive days. Insulin resistance in rat was confirmed by using hypoglycemic activity of glibenclamide on day 120. On the day of 120-134, rats were administered with i.e, metformin 45 mg/kgBW as a positive control, andrographolide 4.5 mg/kgBW, curcumin 45 mg/kgBW, combination andrographolide:curcumin 1:3
format Theses and Dissertations
NonPeerReviewed
author , Indah Solihah
, Prof. Dr. Suwidjiyo Pramono, DEA., Apt.
author_facet , Indah Solihah
, Prof. Dr. Suwidjiyo Pramono, DEA., Apt.
author_sort , Indah Solihah
title ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN
title_short ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN
title_full ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN
title_fullStr ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN
title_full_unstemmed ISOLASI ANDROGRAFOLID DARI HERBA SAMBILOTO (Andrographis paniculata (Burm.f) Ness) DAN EFEK HIPOGLIKEMIKNYA PADA TIKUS RESISTEN INSULIN PADA PEMBERIAN TUNGGAL DAN KOMBINASI DENGAN KURKUMIN
title_sort isolasi andrografolid dari herba sambiloto (andrographis paniculata (burm.f) ness) dan efek hipoglikemiknya pada tikus resisten insulin pada pemberian tunggal dan kombinasi dengan kurkumin
publisher [Yogyakarta] : Universitas Gadjah Mada
publishDate 2014
url https://repository.ugm.ac.id/134260/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=75328
_version_ 1681233831642791936

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