HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS

Background: Laryngeal squamous cell carcinoma is one of most important malignancy in head and neck. This malignancy mostly found in glottis area, about 70% of laryngeal malignancy. HIF-1α is a protein commonly found in solid tumour and plays a crucial role in biological processes under hypoxic condi...

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Main Author: PRIYANTO, PRIYANTO
Format: Theses and Dissertations NonPeerReviewed
Published: [Yogyakarta] : Universitas Gadjah Mada 2015
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Online Access:https://repository.ugm.ac.id/134545/
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spelling id-ugm-repo.1345452016-04-10T11:32:00Z https://repository.ugm.ac.id/134545/ HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS PRIYANTO, PRIYANTO Clinical Sciences Medical Microbiology Background: Laryngeal squamous cell carcinoma is one of most important malignancy in head and neck. This malignancy mostly found in glottis area, about 70% of laryngeal malignancy. HIF-1α is a protein commonly found in solid tumour and plays a crucial role in biological processes under hypoxic conditions especially angiogenesis and carcinogenesis. Aim: This study examine the association between HIF-1α expression levels and clinical stage in glottic squamous cell carcinoma. Methode: This cross sectional study examine the association between HIF-1α expression levels and clinical stage in glottis squamous cell carcinoma. Total 42 paraffin tissue blocks from glottic squamous cell carcinoma patients in pathological department of Dr. Sardjito hospital were examined immunohistochemically to see the expression of HIF-1α using anti HIF-1α monoclonal antibody. Association between HIF-1α expression levels and clinical stage were analysed using chi square test. Result: In Total 42 paraffin tissue blocks from glottic squamous cell carcinoma patients, we found 38 patients in advanced stage (25 positively expressed HIF-1α; 13 negatively expressed HIF-1α) and 4 patients in early stage (2 positively expressed HIF-1α; 2 negatively expressed HIF-1α). From the analysis we found no statistically significant association between HIF-1α protein expression and clinical stage in glottic squamous cell carcinoma (p > 0,05; p = 0,451). Conclusion: There is no statistically significant association between HIF-1α protein expression and clinical stage in glottic squamous cell carcinoma. Keywords: Glottic squamous cell carcinoma, hypoxia inducible factor-1α, immunohistochemical, clinical stage, association [Yogyakarta] : Universitas Gadjah Mada 2015 Thesis NonPeerReviewed PRIYANTO, PRIYANTO (2015) HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS. Masters thesis, UGM. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=77305
institution Universitas Gadjah Mada
building UGM Library
country Indonesia
collection Repository Civitas UGM
topic Clinical Sciences
Medical Microbiology
spellingShingle Clinical Sciences
Medical Microbiology
PRIYANTO, PRIYANTO
HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS
description Background: Laryngeal squamous cell carcinoma is one of most important malignancy in head and neck. This malignancy mostly found in glottis area, about 70% of laryngeal malignancy. HIF-1α is a protein commonly found in solid tumour and plays a crucial role in biological processes under hypoxic conditions especially angiogenesis and carcinogenesis. Aim: This study examine the association between HIF-1α expression levels and clinical stage in glottic squamous cell carcinoma. Methode: This cross sectional study examine the association between HIF-1α expression levels and clinical stage in glottis squamous cell carcinoma. Total 42 paraffin tissue blocks from glottic squamous cell carcinoma patients in pathological department of Dr. Sardjito hospital were examined immunohistochemically to see the expression of HIF-1α using anti HIF-1α monoclonal antibody. Association between HIF-1α expression levels and clinical stage were analysed using chi square test. Result: In Total 42 paraffin tissue blocks from glottic squamous cell carcinoma patients, we found 38 patients in advanced stage (25 positively expressed HIF-1α; 13 negatively expressed HIF-1α) and 4 patients in early stage (2 positively expressed HIF-1α; 2 negatively expressed HIF-1α). From the analysis we found no statistically significant association between HIF-1α protein expression and clinical stage in glottic squamous cell carcinoma (p > 0,05; p = 0,451). Conclusion: There is no statistically significant association between HIF-1α protein expression and clinical stage in glottic squamous cell carcinoma. Keywords: Glottic squamous cell carcinoma, hypoxia inducible factor-1α, immunohistochemical, clinical stage, association
format Theses and Dissertations
NonPeerReviewed
author PRIYANTO, PRIYANTO
author_facet PRIYANTO, PRIYANTO
author_sort PRIYANTO, PRIYANTO
title HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS
title_short HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS
title_full HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS
title_fullStr HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS
title_full_unstemmed HUBUNGAN EKSPRESI PROTEIN HYPOXIA-INDUCIBLE FACTOR-1α DENGAN STADIUM KLINIS PADA KARSINOMA SEL SKUAMOSA GLOTIS
title_sort hubungan ekspresi protein hypoxia-inducible factor-1α dengan stadium klinis pada karsinoma sel skuamosa glotis
publisher [Yogyakarta] : Universitas Gadjah Mada
publishDate 2015
url https://repository.ugm.ac.id/134545/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=77305
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