Immobilization of DNA molecules on the metal surface through alkyl amine for biosensor applications
Efforts to immobilize DNA molecules directly onto the metal surface have been carried out by many researchers. At present, deposition of DNA onto the metal surface of gold is usually carried out through alkylthiol molecules. In this work, DNA molecules were succesfidly deposited on the metal surface...
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| Format: | Article NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2001
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| Online Access: | https://repository.ugm.ac.id/18225/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1003 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Efforts to immobilize DNA molecules directly onto the metal surface have been carried out by many researchers. At present, deposition of DNA onto the metal surface of gold is usually carried out through alkylthiol molecules. In this work, DNA molecules were succesfidly deposited on the metal surface of Indium Tin Oxide (ITO) through alkylamine of octadecylan tine (denoted as ODA). The optical properties characterization was carried out using LIV-Vis spectrometer for DNAs and DNAs mixed with Octadecylamine (denoted as DNAs-ODA) in liquid form. Film depositions of DNAs-ODA on the ITO substrate was also characterized. Based on the observation, it was found that the structure of metal-amine-DNA was potential to be used for DNA sensor applications.ln addition, electrical properties of ODA and DNA300-ODA were characterized by apply* various voltages to the sample and measuring its electrical current flow. It was found that the electrical resistance of ODA
decreased due to the presence of the DNA molecules.
Keywords: immobilization of DNA molecules �biosensor applications |
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