Pengaruh dopamin, dobutamin dan campuran dopamin-dobutamin terhadap tahanan vaskular dan ginjal =The effect ofDopamine, Dobutamine and Mixed Dopamtne-Dobutamine onHind-limband Renal Vascular Resistance

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2001
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/18705/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1506
• Institution: Universitas Gadjah Mada

ABSTRACT The aim of this study was to detect the different effects of dopamine, dobutamine with dosages of 2,5 and 10 mgr/KgBW/minute as well as mixed dopamine-dobutamine on hind-limb and renal vascular resistance. In this study 36 healthy cats of the various strains, male and female, with body weight of 2,43 ± 0,54 Kg were used. The animals were anesthetized and divide into 6 groups. Three groups get each 2,5 and 10 ugr/KgBW/ minute dopamine and followed by adding dobutamine 2, 5 and 10 ugr/ KgBW/minute. The 3 other groups were given dobutamine only as the dopamine groups. Dopamine and dobutamine were given I.V. The hind-limb and renal vascular resistance were calculated by computing the systemic blood pressure and the hind-limb and renal blood flow volume. The hind-limb and renal blood flow volume were observed directly by using a drop recorder mounted on the femoral vein and renal vein. The result of this study was that dopamine 2 ugr/KgBW/minute decreases the renal resistance and systemic blood pressure, but the hind-limb vascular resistance is increasing. Increasing dopamine to 5 and 10 ugr/ KgBW/minute results in the rising of the systemic blood pressure, the renal as well as the hind-limb vascular resistance and the difference is significant (P