Tumor Wilms yang disertai sindroma Cushing - Suatu laporan kasus.

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 1997
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/18714/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=1515
• Institution: Universitas Gadjah Mada

Ectopic ACTH syndrome associated with Wilms tumor is very rare. We reported a case of 6-year-old girl with an abdominal mass and cushingoid appearance. After removal of the mass, which is proved later on to be Wilms tumor by histhopathological study, the Cushings syndrome disappeared. Due to severe side effects, the patient was unable to follow the full course of the post - operative chemotherapy. A year later, the patient returned with recurrence of symptoms, i.e. abdominal mass and Cushings syndrome. Although serum ACTH level was not measured, the symptoms and close association between the tumor and the Cushings syndrome suggested of an ectopic ACTH - secreting Wilms tumor. Key words: ectopic ACTH syndrome - cushingoid appearance - Cushings syndrome - Wilms tumor -abdominal mass Sindroma ACTH ektopik yang menyertai tumor Wilms sangat jarang ditemukan. Dilaporkan sebuah kasus seorang anak perempuan berusia 6 tahun yang datang dengan massa di dalam abdomen dan tanda cushingoid. Setelah massa, yang ternyata kemudian adalah tumor Wilms, diambil gejala sindroma Cushing menghilang. Penderita tidak dapat menyelesaikan kemoterapi pasca bedah karena mengalami efek samping kemoterapi yang berat. Setahun kemudian, penderita kembali karena kambuhnya massa abdomen dan tanda-tanda sindroma Cushing. Meskipun kadar ACTH serum tidak diukur, gejala dan hubungan waktu yang sangat erat antara tumor dengan sindroma Cushing menunJukkan kemungkinan suatu tumor Wilms yang mensekresi ACTH ektopik.