Pengaruh infusa herba meniran (Phyllanthus niruri L.) terhadap efek toksik aflatoksin B1 pada hepar tikus (Rattusnorvegicus) (In Vivo)
ABSTRACT Phyllanthus niruri L. (meniran) is well known and can be used for traditional treatment of various diseases such as jaundice, diarrhea, and infection of tractus urinarius. The studies showed that the extract of Phyllanthus niruri L. could be used as antihepatotoxics. This study was designed...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
1998
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| Online Access: | https://repository.ugm.ac.id/20822/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=3680 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | ABSTRACT
Phyllanthus niruri L. (meniran) is well known and can be used for traditional treatment of various diseases such as jaundice, diarrhea, and infection of tractus urinarius. The studies showed that the extract of Phyllanthus niruri L. could be used as antihepatotoxics. This study was designed to investigate the effect of 10%, 20%, and 30% water-extract of Phyllanthus niruri L. herbs on the rats' liver treated with 15 ug aflatoxin B1 (AFB1) in 0,2 ml propylene glycol, orally by tube, everyday for 16 and 24 weeks. Employing the analysis variance, significant effect was observed in serum glutamate-pyruvate transaminase (SGPT) and liver's cytosol glutamate-pyruvate transaminase (GPT), but was not significant in liver's cytosol glutathione S-transferase IGST). However among inter group analysis, significant decrease in SGPT and liver's cytosol GPT observe only group treated with 20% water-extract of Phyllanthus niruri L. herbs and AFB1 compared to group treated with AFB1 (p |
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