Sindrom Vogt-Koyanagi Harada Laporan Kasus

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 1998
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/20863/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=3721
• Institution: Universitas Gadjah Mada

ABSTRACT The Vogt-Koyanagl-Harada Syndrome is characterized by bilateral panuveitis and exudative retinal detachments, in association with cutaneous and neurosensory manifestations. This syndrome is seen most commonly in darker pigmented races, such as Orientals, Hispanics, American Indians, and blacks. It affects both sexes, although it appears to be a distinct female predominance. Most patients are between 20 to 50 years of age, but children and older adults also may be affected. A patient with some clinical symptoms of Vogt-Koyanagi-Harada (VKH) syndrome was reported. This patient had chronic bilateral iridocyclitis, posterior uveitis, exudative retinal detachment, cataracts related to cutaneous manifestations. This patient well responded on ophthalmologic manifestations by corticosteroid treatment but the other signs of VKH syndrome were still developing after 4 months period. The therapy for VKH syndrome was the high doses of systemic corticosterolds, and, with the severity of the anterior uveitis, topical corticosteroid was administrated frequently. A short-acting corticosteroid such as prednisone, in the range of 100-120 mg/day was given, based on the severity of the Inflammation. Some patients might require the addition of cytotoxic agents or cyclosporine. Key words : Vogt-Kayanagi-Harada syndrome - bilateral iridocyclitis - exudative retinal detachment cutaneous manifestations. Sindrom Vogt-Koyanagi-Harada secara khas ditandai dengan panuveitis bilateral dan ablasi retina eksudatif dan berhubungan pula dengan berbagal manifestasi dermatologik dan neurosensorik. Sindrom ini lebih sering terjadl pada ras dengan pigmen lebih banyak, seperti Oriental, Hispanik, Indian Amerika, dan kulit hitam. Penyakit int dapat mengenal laki-laki maupun perempuan, meskipun timbul predominan pada perempuan. Pasien terbanyak pada usia antara 20 sampal 50 tahun, tetapi anak-anak dan orang tua dapat juga terkena. Dilaporkan seorang penderita dengan berbagal gejala klinis dart sindrom Vogt-Koyanagi-Harada (VKH). Gejala pada pasien ini meliputi iridosiklitis bilateral kronik, uveitis posterior, ablasi retina eksudatif, katarak, disertai manifestasi dermatologis. Pasien memberlkan respon kesembuhan yang baik pada gejala oftalmologis dengan pemberian kortikosterold, walaupun demikian tanda dan gejala lain dari sindrom VKH tetap berlanjut setelah 4 bulan. Terapi untuk sindrom VKH berupa kortikosteroid sistemik dosis tinggi, dan bile uveitis anteriornya berat, diberikan tambahan kortikosterold topikal dengan pemakaian yang sering. Kortikosteroid aksi pendek seperti prednlson, dapat diberikan dalam dosis 100-120 mg/hari, berdasarkan tingkat keparahan