Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid

ABSTRACT Arif Nurrochmad - Role and psychological dependenci arrangement of opioid by type of reseptor opioid Opioid receptor can be classified as p., 8, and K-opioid receptor that widely expressed in the CNS. The development of selective receptor agonist and cloning of each receptor have contribute...

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Main Author: Perpustakaan UGM, i-lib
Format: Article NonPeerReviewed
Published: [Yogyakarta] : Universitas Gadjah Mada 2004
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Online Access:https://repository.ugm.ac.id/21454/
http://i-lib.ugm.ac.id/jurnal/download.php?dataId=4316
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spelling id-ugm-repo.214542014-06-18T00:28:58Z https://repository.ugm.ac.id/21454/ Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid Perpustakaan UGM, i-lib Jurnal i-lib UGM ABSTRACT Arif Nurrochmad - Role and psychological dependenci arrangement of opioid by type of reseptor opioid Opioid receptor can be classified as p., 8, and K-opioid receptor that widely expressed in the CNS. The development of selective receptor agonist and cloning of each receptor have contributed greatly to our increasing knowledge of the neuropharmacological profile of each opioid receptor type. This review focuses on the functional interaction among these opioid receptor types that contribute to opioid dependence especially in psychological dependence. Several lines of evidence provide arguments to support substantial roles for p-opioid receptors and the possible involvement of 8-opioid receptors in the development of physical and psychological dependence on morphine. Many studies have pointed to the mesolimbic dopaminergic system projecting from the ventral tegmental area to the nucleus accumbens as a critical site for the initiation of psychological dependence on opioids. It is important to note as the broad existence of opposing interaction between p/8-, and K-receptors in the central nervous system. The activation of Kopioid receptors leads to the suppression of unpleasant p.- or 8-mediated side effects such as withdrawal and rewarding effect. Considering the functional interaction among opioid receptor types, the co-administration of morphine-like compounds with K-receptor agonists lead suppressing the side effects of p-opioid receptor agonist that benefit for the pain management. Key words: Opioid receptor � receptor types � psychological dependence � morphine [Yogyakarta] : Universitas Gadjah Mada 2004 Article NonPeerReviewed Perpustakaan UGM, i-lib (2004) Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid. Jurnal i-lib UGM. http://i-lib.ugm.ac.id/jurnal/download.php?dataId=4316
institution Universitas Gadjah Mada
building UGM Library
country Indonesia
collection Repository Civitas UGM
topic Jurnal i-lib UGM
spellingShingle Jurnal i-lib UGM
Perpustakaan UGM, i-lib
Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
description ABSTRACT Arif Nurrochmad - Role and psychological dependenci arrangement of opioid by type of reseptor opioid Opioid receptor can be classified as p., 8, and K-opioid receptor that widely expressed in the CNS. The development of selective receptor agonist and cloning of each receptor have contributed greatly to our increasing knowledge of the neuropharmacological profile of each opioid receptor type. This review focuses on the functional interaction among these opioid receptor types that contribute to opioid dependence especially in psychological dependence. Several lines of evidence provide arguments to support substantial roles for p-opioid receptors and the possible involvement of 8-opioid receptors in the development of physical and psychological dependence on morphine. Many studies have pointed to the mesolimbic dopaminergic system projecting from the ventral tegmental area to the nucleus accumbens as a critical site for the initiation of psychological dependence on opioids. It is important to note as the broad existence of opposing interaction between p/8-, and K-receptors in the central nervous system. The activation of Kopioid receptors leads to the suppression of unpleasant p.- or 8-mediated side effects such as withdrawal and rewarding effect. Considering the functional interaction among opioid receptor types, the co-administration of morphine-like compounds with K-receptor agonists lead suppressing the side effects of p-opioid receptor agonist that benefit for the pain management. Key words: Opioid receptor � receptor types � psychological dependence � morphine
format Article
NonPeerReviewed
author Perpustakaan UGM, i-lib
author_facet Perpustakaan UGM, i-lib
author_sort Perpustakaan UGM, i-lib
title Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
title_short Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
title_full Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
title_fullStr Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
title_full_unstemmed Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
title_sort peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid
publisher [Yogyakarta] : Universitas Gadjah Mada
publishDate 2004
url https://repository.ugm.ac.id/21454/
http://i-lib.ugm.ac.id/jurnal/download.php?dataId=4316
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