FACTORS INFLUENCING ON DIAZEPAM HOMOGENEITY IN BINARY INTERACTIVE MIXTURE WITH DIFFERENT CARRIERS = FAKTOR-FAKTOR YANG BERPENGARUH PADA HOMOGENITAS DIAZEPAM DALAM CAMPURAN INTERAKTIF BJNER DENGAN BERBAGAI PEMBAWA
ABSTRACT Interactive mixing requires an interaction between particles, i.e. interaction of fine particles with the surface of larger particles as the carrier. Two type of forces exist at the particle interface : adhesion and detachment force. The interactive mixing process should depend on carrier p...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
1999
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| Online Access: | https://repository.ugm.ac.id/21524/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=4389 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | ABSTRACT
Interactive mixing requires an interaction between particles, i.e. interaction of fine particles with the surface of larger particles as the carrier. Two type of forces exist at the particle interface : adhesion and detachment force. The interactive mixing process should depend on carrier particle size, fine particles concentration and affinity of the carrier.
Interactive mixtures were made by using diazepam in different concentration with carrier in different types and particle sizes. The mixing process was done in a cube mixer. The degree of affinity of the carrier surface to diazepam was determined by ultracentrifuge method. The conclusion and recommendation from this study were to use Emdex and lactose-strach granules as the carrier for the further studies. Emdex and lactose-starch granules represent the carrier having high and low affinity for diazepam respectively. Result showed that time needed for a satisfactory degree of homogeneity for the diazepam (0,25%) lactose granule interactive mixtures was dependent on the carrier particle size. The homogeneity of the micronized diazepam lactose granule (250-425 pm) mixture at different diazepam concentration also showed the time dependency. But for Emdex as the carrier there was little effect of diazepam concentration and particle size of Emdex in the mixing time needed for satisfactory degree of mixtures homogeneity.
It can be concluded that the homogeneity of the binary interactive mixture was affected by the affinity, and particle size of the carrier and, the concentration of diazepam as well.
Key words : interactive mixture, homogeneity, diazepam |
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