Efek aspirin dosis rendah (30 mg) terhadap agregasi platelet pada perokok

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2001
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/22184/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=5066
• Institution: Universitas Gadjah Mada

Background: It's been well reported that smoking increases platelet aggregation rate, which consequently increases the cerebrovascular risk. Low-dose aspirin (30 mg a day) could inhibit platelet aggregation tendency. However, there has been no agreement whether low-dose aspirin could inhibit platelet aggregation in smokers. Aims: The aim of this study is to determine whether low-dose aspirin will reduce platelet aggregation tendency in smokers. Materials and method: The study design was a parallel, randomized, double-blind clinical study. Subjects: Male, 20-40 years old, smokers, not under aspirin treatment. Sample size: 70 subjects in each group. Statistical analysis: The statistical analysis used in this study was students' f-test Results: One week low-dose aspirin treatment can significantly decrease the platelet aggregation rate as compared with placebo, either in 30 seconds or maximum platelet aggregation (p