HUBUNGAN ANTARA DERAJAT KEGANASAN HISTOLOGIS DENGAN DERAJAT INFILTRAT SEL T SITOTOKSIK PADA ADENOKARSINOMA PROSTAT = THE CORRELATION BETWEEN HISTOLOGIC GRADING AND DEGREE OF T CELL CYTOTOXIC INFILTRATION AMONG PROSTATI
The correlation between cytotoxic T cells infiltrate and grade of malignancy is still controver¬sial. Some tumors like: medullary breast cancer and pancreatic cancer, indicates a negative correlation between cytotoxic T cells infiltration and tumor pregression, but the presence of cytotoxic T cells...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
2002
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| Online Access: | https://repository.ugm.ac.id/22344/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=5241 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | The correlation between cytotoxic T cells infiltrate and grade of malignancy is still controver¬sial. Some tumors like: medullary breast cancer and pancreatic cancer, indicates a negative correlation between cytotoxic T cells infiltration and tumor pregression, but the presence of cytotoxic T cells in anaplastic large cell lymphoma is not related to clinical out come of the disease. The role of cytotoxic T cell infiltrates in prostatic adenocarcinomas is still unclear till now. The aim of this study was to find out the correlation between the amount of cytotoxic T cell infiltrates and histological grading of prostatic adenocarcinoma. Thirty paraffin block of prostatic adenocarcinomas were selected randomly and stained immunohistochemically with anti CD 8 and anti CD3 MoAB, counterstained with Harris Hematoxylene. The positive CD8 and CD3 of infiltrates intratumor and peritumor was counted and analyzed with one way Anova statistically. The result showed that there was a significant difference statisti¬cally (P 0,05) of these variables. As a conclusion, the poorest histolo¬gical grading of prostatic adenocarcinoma has the most intratumor cytotoxic T cell infiltration.
Key words: cytotoxic T cells |
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