Penggunaan bakteriofaga untuk terapeksperimental sepsis yang disebabkan salmonellatyphi pada kelincii
ABSTRACT Bacteriophages are viruses which specifically infect bacteria. As natural predator of bacteria, bacteriphage may be useful in treatment of bacterial infections. Previous studies have proved the advantage of bacteriophage for treatment of bacterial infection in animal laboratory or human/pat...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
2004
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| Online Access: | https://repository.ugm.ac.id/24130/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=7100 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | ABSTRACT
Bacteriophages are viruses which specifically infect bacteria. As natural predator of bacteria, bacteriphage may be useful in treatment of bacterial infections. Previous studies have proved the advantage of bacteriophage for treatment of bacterial infection in animal laboratory or human/patients.
The aim of this study is to evaluate the efficacy of bacteriphage for treatment of rabbits infected with Salmonella typhi. Eighteen rabbits were infected with 108cfu/m1S. typhi intravenously. The rabbits then divided into three groups, i.e. the rabbits treated with 10B pfu/ml specific phages for S. typhi, untreated and as control. Each group has rabbits for examining bacterial numbers and for observing the duration of infection.
Result showed that the number of S. typhi found in liver, spleen and lung of phage-treated rabbit were much lower than that of untreated rabbit. In conclusion bacteriophaga is effective for giving an experimental sepsis therapy caused by S. typhi in rabbit, bacteriologically.
Keywords: bacteriophage, Salmonella typhi, intravenously |
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