A Novel Reversed Phase High Performance Liquid Chromatography Method To Accurately Determine Low Concentrations Of Curcumin In Rat Plasma

• Main Authors: Setyaningsih, Dewi, Murti, Yosi Bayu, Martono, Sudibyo, Hinrichs, W.L.J, Hertiani, Triana, Fudholi, Achmad
• Format: Article PeerReviewed
• Language: English
• Published: International Journal of Pharmaceutical and Clinical Research 2016
• Subjects: Pharmaceutical Sciences
• Online Access: https://repository.ugm.ac.id/273442/1/A%20Novel%20Reversed%20Phase%20High%20Performance%20Liquid%20Chromatography%20Method%20To%20Accurately%20Determine%20Low%20Concentrations%20Of%20Curcumin%20In%20Rat%20Plasma-Triana%20Hertiani.pdf; https://repository.ugm.ac.id/273442/; http://www.ijpcr.com
• Institution: Universitas Gadjah Mada

Due to its lipophilic nature, curcumin levels in plasma are very low after oral administration, and therefore hard to detect. A number of chromatographic methods, including LC/MS have been developed. Although the LC/MS method is sensitive, the matrix effect can be difficult to handle. Fu...