Effect Of Hydrogel Dressing Copolymer Poli(Vinylpirrolidone) (Pvp) - K- Carrageenan Prepared By Radiation And Healing Times On The Radius Reductions Burn Injuried Of Wist Ar White Rat = Pembalut Hldrogel Kopollmer....
ABSTRACT The pre-clinical study of poly (vinyl pirrolidone) (PVP)-K- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing bum injuried in the rats. The hydrogels wenJ prepared by r-irradiation of aqueous solutions of 15 wt.-% PVP and 2...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
2008
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| Online Access: | https://repository.ugm.ac.id/27357/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10413 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | ABSTRACT
The pre-clinical study of poly (vinyl pirrolidone) (PVP)-K- carrageenan hydrogel has been carried out. The aim of this study is to investigate the effect of hydrogel for healing bum injuried in the rats. The hydrogels wenJ prepared by r-irradiation of aqueous solutions of 15 wt.-% PVP and 2 wt.-% K- carrageenan at a sterilization dose of 25 kGy. The physico-chemical properties of hydrogels were investigated.. The results showed that the hydrogels suitable as candidate for wound dressing with gel fraction of 90:t 5 (%), the water absorption was 4500 :r 55 (WIW),
the water content was 83 :t 2 (0"'), tensile .strength was 1,5 :t 0, 1 kg/cm2 and adhesiveness was O. The effect of the hydrogel as wound dressing was evaluated by attaching to a bum of the back skin of rats as a function of time observation. Advantages of the hydrogel were slightly faster rate of reducing radius diameter of injured bum skin, easy removal without damage to renewed skin.
Keywords: hydrogel, irradiation, copolymer, PVP, 1( carrageenan, |
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