Expression of MRP8/MRP14mRNAin Monocytes of Periodontitis: Comparison between Diabetic and Non Diabetic Patients
The severity of periodontitis on patients with type 2 Diabetes Mellitus patients was strongly thought caused by decreasing of leukocytes function such as monoctyes and neutrophils. In our previous research it was found that calprotectin (MRP8/MRP14) level in leukocytes of periodontitis patients with...
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| Format: | Article NonPeerReviewed |
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[Yogyakarta] : Universitas Gadjah Mada
2010
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| Online Access: | https://repository.ugm.ac.id/27843/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=10906 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | The severity of periodontitis on patients with type 2 Diabetes Mellitus patients was strongly thought caused by decreasing of leukocytes function such as monoctyes and neutrophils. In our previous research it was found that calprotectin (MRP8/MRP14) level in leukocytes of periodontitis patients with type 2 DMwas higher than periodontitis in non DM.The aim of this study was to determine calprotectin (MRP8/MRP14) mRNAexpression in human monocytes of periodontitis patients with type 2DMand without DM.Monocytes were isolated from the peripheral blood of periodontitis patients with uncontrolled type 2 DM,controlled type 2 DM,and non DM.The expression of total RNAcalprotectin (MRP8and MRP14)were detected by RTPCRusing GAPDHas the innate control. It was observed that the value of MRP8/MRP14mRNAexpression DMpatients were higher than non DM,and the highly significant increase expression (p |
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