Synthesis of 3-(4’-nitrophenyl)-4,5-Dihydro Pyrazole-Based and Its In-vitro Antibacterial Test

• Main Authors: Fauzi’ah, Lina, Wahyuningsih, Tutik Dwi
• Format: Conference or Workshop Item PeerReviewed
• Language: English
• Published: 2022
• Subjects: Mathematics and Applied Sciences
• Online Access: https://repository.ugm.ac.id/278574/1/Wahyuningsih_MA.pdf; https://repository.ugm.ac.id/278574/; https://pubs.aip.org/aip/acp/article-abstract/2468/1/040001/2826621/Synthesis-of-3-4-nitrophenyl-4-5-dihydro-pyrazole?redirectedFrom=fulltext
• Institution: Universitas Gadjah Mada

Pyrazoline has been reported with a broad spectrum of biological activity. The presence of the withdrawing group especially the 4-nitrophenyl group in the 3 th ring of pyrazoline has never been performed. A new derivative of 2- pyrazoline has been synthesized in 2-butanol as solvent. Surprisingly, pyrazoline was synthesized by cyclization of chalcone and hydrazine hydrate without acetate acid as a catalyst. Reactants were refluxed for 30 hours and controlled by Thin Layer Chromatography (TLC). The result showed that the reaction yielded 45.07% red solid pyrazoline. Characterization of the structure was confirmed by FTIR and 1H- NMR spectra. However, in vitro antibacterial study showed that the compound has very low antibacterial activity.