Allopurinol-Induced Stevens–Johnson Syndrome in Javanese Men With Positive HLA-B*58:01
Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens–Johnson syndrome (SJS). SJS induced by allopu...
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| Main Authors: | , , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English |
| Published: |
Frontier
2022
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/278649/1/Ferdiana_KKMK.pdf https://repository.ugm.ac.id/278649/ https://www.frontiersin.org/articles/10.3389/fgene.2022.839154/full https://doi.org/10.3389/fgene.2022.839154 |
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| Institution: | Universitas Gadjah Mada |
| Language: | English |
| Summary: | Background: Allopurinol is the most commonly used drug for the treatment of gout arthritis. However, the use of allopurinol is associated with severe cutaneous adverse
reactions (SCARs) and life-threatening immune-mediated reactions that include Stevens–Johnson syndrome (SJS). SJS induced by allopurinol is strongly linked with the presence of HLA-B*58:01 in the Asian population. Such a study has not been conducted in Indonesia. We present two cases with clinical diagnosis of SJS. These patients had Javanese ethnicity, for which evidence on the genetic predisposition of allopurinol-induced SJS/TEN had not been established. Testing for the presence of the HLA-Bp58:01 allele was positive in both cases. Our case report confirms findings from studies in Asian countries that link HLA-B*58:01 and allopurinol-induced SJS/TEN. A larger study is needed to elicit evidence that the HLA-B*58:01 allele can potentially be used as a genetic marker for allopurinol-induced SCARs among different ethnicities in Indonesia. |
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