Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2
Several types of vaccines have been developed to prevent the coronavirus disease 2019 (COVID-19). It is important to understand whether demographic and clinical variables affect the effectiveness of various types of vaccines. This study analysed the association between demographic/clinical factors,...
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Elsevier Ltd
2022
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Online Access: | https://repository.ugm.ac.id/278874/1/Hypertension%20is%20associated%20with%20antibody%20response%20and%20breakthrough%20infection%20in%20health%20care%20workers%20following%20vaccination%20with%20inactivated%20SARS-CoV-2.pdf https://repository.ugm.ac.id/278874/ https://www.sciencedirect.com/science/article/pii/S0264410X22006764?via%3Dihub https://doi.org/10.1016/j.vaccine.2022.05.059 |
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id-ugm-repo.2788742023-10-18T05:19:48Z https://repository.ugm.ac.id/278874/ Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 Soegiarto, Gatot Wulandari, Laksmi Purnomosari, Dewajani Fahmita, Karin Dhia Gautama, Hendra Ikhwan Hadmoko, Satrio Tri Prasetyo, Muhammad Edwin Mahdi, Bagus Aulia Arafah, Nur Prasetyaningtyas, Dewi Negoro, Pujo Prawiro Prakoeswa, Cita Rosita Sigit Endaryanto, Anang Suprabawati, Desak Gede Agung Tinduh, Damayanti Rachmad, Eka Basuki Triyono, Erwin Astha Wahyuhadi, Joni Keswardiono, Catur Budi Wardani, Feby Elyana Mayorita, Fitriyah Kristiani, Nunuk Baskoro, Ari Fetarayani, Deasy Nurani, Wita Kartika Oceandy, Delvac Cardiovascular Medicine and Haematology Respiratory Diseases Medical Physiology Public Health and Health Services Several types of vaccines have been developed to prevent the coronavirus disease 2019 (COVID-19). It is important to understand whether demographic and clinical variables affect the effectiveness of various types of vaccines. This study analysed the association between demographic/clinical factors, antibody response and vaccine effectiveness in healthcare workers vaccinated with inactivated virus. We enrolled 101 healthcare workers who received two doses of inactivated viral vaccine (CoronaVac). Blood samples were analysed at 1, 3, and 5 months after the second dose of vaccination. Data regarding demographic characteristics, medical histories, and clinical parameters were collected by interview and medical examination. In a separate retrospective study, we analysed the incidence of vaccine breakthrough infection on 2714 healthcare workers who received two doses of inactivated viral vaccine. Medical histories and demographic data were collected using a structured self-reported questionnaire. We found that antibody titres markedly increased at 1 month after vaccination but gradually decreased at 3–5 months post-vaccination. We observed a significant association between age (≥40 years) and antibody level, whereas sex and body mass index (BMI) exhibited no effect on antibody titres. Amongst clinical variables analysed, high blood pressure and history of hypertension were significantly correlated with lower antibody titres. Consistently, we found a significant association in the retrospective study between hypertension and the incidence of breakthrough infection. In conclusion, our results showed that hypertension is associated with lower antibody titres and breakthrough infection following COVID-19 vaccination. Thus, blood pressure control might be important to improve the efficacy of inactivated virus vaccine. Elsevier Ltd 2022-06-26 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/278874/1/Hypertension%20is%20associated%20with%20antibody%20response%20and%20breakthrough%20infection%20in%20health%20care%20workers%20following%20vaccination%20with%20inactivated%20SARS-CoV-2.pdf Soegiarto, Gatot and Wulandari, Laksmi and Purnomosari, Dewajani and Fahmita, Karin Dhia and Gautama, Hendra Ikhwan and Hadmoko, Satrio Tri and Prasetyo, Muhammad Edwin and Mahdi, Bagus Aulia and Arafah, Nur and Prasetyaningtyas, Dewi and Negoro, Pujo Prawiro and Prakoeswa, Cita Rosita Sigit and Endaryanto, Anang and Suprabawati, Desak Gede Agung and Tinduh, Damayanti and Rachmad, Eka Basuki and Triyono, Erwin Astha and Wahyuhadi, Joni and Keswardiono, Catur Budi and Wardani, Feby Elyana and Mayorita, Fitriyah and Kristiani, Nunuk and Baskoro, Ari and Fetarayani, Deasy and Nurani, Wita Kartika and Oceandy, Delvac (2022) Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2. Vaccine, 40 (30). pp. 4046-4056. ISSN 0264410X https://www.sciencedirect.com/science/article/pii/S0264410X22006764?via%3Dihub https://doi.org/10.1016/j.vaccine.2022.05.059 |
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Cardiovascular Medicine and Haematology Respiratory Diseases Medical Physiology Public Health and Health Services Soegiarto, Gatot Wulandari, Laksmi Purnomosari, Dewajani Fahmita, Karin Dhia Gautama, Hendra Ikhwan Hadmoko, Satrio Tri Prasetyo, Muhammad Edwin Mahdi, Bagus Aulia Arafah, Nur Prasetyaningtyas, Dewi Negoro, Pujo Prawiro Prakoeswa, Cita Rosita Sigit Endaryanto, Anang Suprabawati, Desak Gede Agung Tinduh, Damayanti Rachmad, Eka Basuki Triyono, Erwin Astha Wahyuhadi, Joni Keswardiono, Catur Budi Wardani, Feby Elyana Mayorita, Fitriyah Kristiani, Nunuk Baskoro, Ari Fetarayani, Deasy Nurani, Wita Kartika Oceandy, Delvac Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 |
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Several types of vaccines have been developed to prevent the coronavirus disease 2019 (COVID-19). It is important to understand whether demographic and clinical variables affect the effectiveness of various types of vaccines. This study analysed the association between demographic/clinical factors, antibody response and vaccine effectiveness in healthcare workers vaccinated with inactivated virus. We enrolled 101 healthcare workers who received two doses of inactivated viral vaccine (CoronaVac). Blood samples were analysed at 1, 3, and 5 months after the second dose of vaccination. Data regarding demographic characteristics, medical histories, and clinical parameters were collected by interview and medical examination. In a separate retrospective study, we analysed the incidence of vaccine breakthrough infection on 2714 healthcare workers who received two doses of inactivated viral vaccine. Medical histories and demographic data were collected using a structured self-reported questionnaire. We found that antibody titres markedly increased at 1 month after vaccination but gradually decreased at 3–5 months post-vaccination. We observed a significant association between age (≥40 years) and antibody level, whereas sex and body mass index (BMI) exhibited no effect on antibody titres. Amongst clinical variables analysed, high blood pressure and history of hypertension were significantly correlated with lower antibody titres. Consistently, we found a significant association in the retrospective study between hypertension and the incidence of breakthrough infection. In conclusion, our results showed that hypertension is associated with lower antibody titres and breakthrough infection following COVID-19 vaccination. Thus, blood pressure control might be important to improve the efficacy of inactivated virus vaccine. |
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Article PeerReviewed |
author |
Soegiarto, Gatot Wulandari, Laksmi Purnomosari, Dewajani Fahmita, Karin Dhia Gautama, Hendra Ikhwan Hadmoko, Satrio Tri Prasetyo, Muhammad Edwin Mahdi, Bagus Aulia Arafah, Nur Prasetyaningtyas, Dewi Negoro, Pujo Prawiro Prakoeswa, Cita Rosita Sigit Endaryanto, Anang Suprabawati, Desak Gede Agung Tinduh, Damayanti Rachmad, Eka Basuki Triyono, Erwin Astha Wahyuhadi, Joni Keswardiono, Catur Budi Wardani, Feby Elyana Mayorita, Fitriyah Kristiani, Nunuk Baskoro, Ari Fetarayani, Deasy Nurani, Wita Kartika Oceandy, Delvac |
author_facet |
Soegiarto, Gatot Wulandari, Laksmi Purnomosari, Dewajani Fahmita, Karin Dhia Gautama, Hendra Ikhwan Hadmoko, Satrio Tri Prasetyo, Muhammad Edwin Mahdi, Bagus Aulia Arafah, Nur Prasetyaningtyas, Dewi Negoro, Pujo Prawiro Prakoeswa, Cita Rosita Sigit Endaryanto, Anang Suprabawati, Desak Gede Agung Tinduh, Damayanti Rachmad, Eka Basuki Triyono, Erwin Astha Wahyuhadi, Joni Keswardiono, Catur Budi Wardani, Feby Elyana Mayorita, Fitriyah Kristiani, Nunuk Baskoro, Ari Fetarayani, Deasy Nurani, Wita Kartika Oceandy, Delvac |
author_sort |
Soegiarto, Gatot |
title |
Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 |
title_short |
Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 |
title_full |
Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 |
title_fullStr |
Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 |
title_full_unstemmed |
Hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated SARS-CoV-2 |
title_sort |
hypertension is associated with antibody response and breakthrough infection in health care workers following vaccination with inactivated sars-cov-2 |
publisher |
Elsevier Ltd |
publishDate |
2022 |
url |
https://repository.ugm.ac.id/278874/1/Hypertension%20is%20associated%20with%20antibody%20response%20and%20breakthrough%20infection%20in%20health%20care%20workers%20following%20vaccination%20with%20inactivated%20SARS-CoV-2.pdf https://repository.ugm.ac.id/278874/ https://www.sciencedirect.com/science/article/pii/S0264410X22006764?via%3Dihub https://doi.org/10.1016/j.vaccine.2022.05.059 |
_version_ |
1781413307094138880 |