ANTI-MALARIALCOMPOUND FROM THE STEM BARK OF Erythr/na variegata

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2009
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/28012/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11075
• Institution: Universitas Gadjah Mada

ABSTRACT During the course of our continuing search for novel anti-malarial compounds from Indonesian plants, the methanol extract of the bark of E. variegata showed significant.anti-malarial activity toward Plasmodium falciparum in vitro using the lactate dehydrogenase (LDH) assay. The methanol extract of the bark of E. varlegata was separated by using bioassay-guide fractionation. The ethyl acetate fraction showed the most activity, exhibiting equlpotency against both strains of parasite with IC50of 23.8 pg/mL against 3D7 and 9.3 pg/mL against K1. Furthermore, by using the anti-malarial activity to follow separation, the ethyl acetate fraction was separated by combination of column chromatography to yield an active compound. The chemical structure of active compound was determined on the basis of spectroscopic evidences and comparison with those previously reported and identified as an isoflavonold, warangalone. The warangalone showed anti-malarial activity against both strains of parasite used with IC50of 4.8 pg/mL against 3D7 and 3.7 pg/mL against K1.