STABILITYOF KETOPROFENCOATEDBYCHITOSAN-GUARGUMGEL Stabilitas Ketoprofen Tersalut Gel Kitosan-Gom Guar
ABSTRACT The coating stability of ketoprofen by chitosan-guargum gel has been studied. Into 228.6 mL of 1.75% (w/v) chitosan solution in 1% (v/v) acetic acid, 38.1 mL of guar gum (gg) solution was added with concentration variation of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules, and sti...
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| Format: | Article NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2009
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| Online Access: | https://repository.ugm.ac.id/28026/ http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11089 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | ABSTRACT
The coating stability of ketoprofen by chitosan-guargum gel has been studied. Into 228.6 mL of 1.75% (w/v)
chitosan solution in 1% (v/v) acetic acid, 38.1 mL of guar gum (gg) solution was added with concentration variation
of 0.35, 0.55, and 0.75% (w/v) for ketoprofen microcapsules, and stirred with magnetic stirrer until homogenous.
Afterwards, 7.62mL of glutaraldehyde (glu) was added slowly under stirring, with concentrations varied: 3, 3.5, and
4% (v/v). All mixtures were shaked for 20 min for homogenization. Into each microcapsule mixture for ketoprofen, a
solution of 2 g of ketoprofen in 250 mL of 96% ethanol was added. Every mixture was then added with 5 mL of 2%
Tween-80 and stirred with magnetic stirrer for an hour at room temperature. Conversion of suspension into fine
powders/granules (microcapsules) was done by using spray dryer. Every microcapsule formula was packed into
capsules, as much as 100g per capsule. The capsules were contained in 100-mLdark bottles and the bottles were
kept in climatic chamber at (40:t 2) °C and RH (75 :t 5) % for 3 months. The microcapsule stabilities were tested
chemically and physically. The result showed that formulation of ketoprofen preparation composed of 1.75% (w/v)
chitosan, 0.35% (w/v) gg, and 3.50% (v/v) glu, was relatively the best, with ketoprofen percentage left in
microcapsule after 3 months, degradation rate constant, and shelf life of 80.33%, 0.0351 % week-f, and 18.92
months, respectively. Reaction kinetic model for this formula followed Prout-Tompkinsequation and the degradation
of ketoprofen was seem to follow autocatalytic reaction mechanism controlled by the formation and growth of
reaction core. |
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