ANALYSIS OF IFN-yCONCENTRATION INWISTAR RAT BLOOD AFTER ORAL ADMINISTRATIONOF STANDARDIZED GREEN TEA WATER EXTRACT

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2010
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/28111/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=11174
• Institution: Universitas Gadjah Mada

ABSTRACT Green tea and its polyphenols have been studied extensively as cancer chemopreventive agents in recent years. However, the mechanisms of action are still not clearly understood. Some researchers suggest that immune system plays important role to destroy cancer cells. Because of that reason, the present study was designed to analyse the effects of oral administration standardized green tea water extract on increasing of IFN-y blood concentration and to elucidate possible mechanismsinvolved in the inhibitory action of the cancer development. Two groups (male and female) of 5 rats have given p.o. administration 1.25%of standardizedgreen tea water extract and got 300 mg of (-)-epigal/ocatechingal/ate (EGCG)/kg body weight, while two groups others (male and female) were used as control. We found that IFN-y blood concentration on male and female Wistar rat are significantly increase with 13.11% and 17.59%, respectively (p::,0.05)by ELISA method, whereas control had no increase. These results indicate that standardized green tea water extract has possibility to prevent and suppress cancer development through enhancing IFN-r expressionand other immunosurveil/ ancecomponent. Keywords: Green tea water extract, IFN-y, ELISA