Chiral Separation of Econazole by High Performance Liquid Chromatography Method using Cyclodextrin as Chiral Column

• Main Authors: Hermawan, Dadan, Cacu, Cacu, Salsabila, Khansa, Suwandri, Suwandri, Fatoni, Amin, Sulaeman, Uyi, Iswanto, Ponco, Mudasir, Mudasir, Aboul-Enein, Hassan Y.
• Format: Article PeerReviewed
• Language: English
• Published: Universitas Jenderal Soedirman 2022
• Subjects: Chemical Science; Mathematics and Applied Sciences
• Online Access: https://repository.ugm.ac.id/281842/1/Chiral%20Separation%20of%20Econazole%20by%20High%20Performance%20Liquid%20Chromatography%20Method%20using%20Cyclodextrin%20as%20Chiral%20Column.pdf; https://repository.ugm.ac.id/281842/; https://www.scopus.com/record/display.uri?eid=2-s2.0-85135017452&doi=10.20884%2f1.jm.2022.17.2.6348&origin=inward&txGid=459621c041781b342c34e69ed1e159f8; https://doi.org/10.20884/1.jm.2022.17.2.6348
• Institution: Universitas Gadjah Mada

The chiral separation of econazole, an antifungal drug with one chiral center has been successfully carried out using the high-performance liquid chromatography (HPLC) method. Enantioresolution of econazole (Rs = 2.29) was achieved using cyclodextrin-based chiral column (Astec Cyclobond, 25 cm × 4.6...