Following Polymer Degradation with Nanodiamond Magnetometry

Degradable polymers are widely used in the biomedical fields due to non-toxicity and great biocompatibility and biodegradability, and it is crucial to understand how they degrade. These polymers are exposed to various biochemical media in medical practice. Hence, it is important to precisely follow...

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Main Authors: Li, Runrun, Vedelaar, Thea, Mzyk, Aldona, Morita, Aryan, Padamati, Sandeep Kumar, Schirhagl, Romana
Format: Article PeerReviewed
Language:English
Published: American Chemical Society 2022
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Online Access:https://repository.ugm.ac.id/282743/1/Morita_KG.pdf
https://repository.ugm.ac.id/282743/
https://pubs.acs.org/doi/10.1021/acssensors.1c01782
https://doi.org/10.1021/acssensors.1c01782
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Institution: Universitas Gadjah Mada
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spelling id-ugm-repo.2827432023-11-16T07:30:48Z https://repository.ugm.ac.id/282743/ Following Polymer Degradation with Nanodiamond Magnetometry Li, Runrun Vedelaar, Thea Mzyk, Aldona Morita, Aryan Padamati, Sandeep Kumar Schirhagl, Romana Dentistry Degradable polymers are widely used in the biomedical fields due to non-toxicity and great biocompatibility and biodegradability, and it is crucial to understand how they degrade. These polymers are exposed to various biochemical media in medical practice. Hence, it is important to precisely follow the degradation of the polymer in real time. In this study, we made use of diamond magnetometry for the first time to track polymer degradation with nanoscale precision. The method is based on a fluorescent defect in nanodiamonds, which changes its optical properties based on its magnetic surrounding. Since optical signals can be read out more sensitively than magnetic signals, this method allows unprecedented sensitivity. We used a specific mode of diamond magnetometry called relaxometry or T1 measurements. These are sensitive to magnetic noise and thus can detect paramagnetic species (gadolinium in this case). Nanodiamonds were incorporated into polylactic acid (PLA) films and PLA nanoparticles in order to follow polymer degradation. However, in principle, they can be incorporated into other polymers too. We found that T1 constants decreased gradually with the erosion of the film exposed to an alkaline condition. In addition, the mobility of nanodiamonds increased, which allows us to estimate polymer viscosity. The degradation rates obtained using this approach were in good agreement with data obtained by quartz crystal microbalance, Fourier-transform infrared spectroscopy, and atomic force microscopy. American Chemical Society 2022-01-04 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/282743/1/Morita_KG.pdf Li, Runrun and Vedelaar, Thea and Mzyk, Aldona and Morita, Aryan and Padamati, Sandeep Kumar and Schirhagl, Romana (2022) Following Polymer Degradation with Nanodiamond Magnetometry. ACS Sensors, 7 (1). pp. 123-130. ISSN 23793694 https://pubs.acs.org/doi/10.1021/acssensors.1c01782 https://doi.org/10.1021/acssensors.1c01782
institution Universitas Gadjah Mada
building UGM Library
continent Asia
country Indonesia
Indonesia
content_provider UGM Library
collection Repository Civitas UGM
language English
topic Dentistry
spellingShingle Dentistry
Li, Runrun
Vedelaar, Thea
Mzyk, Aldona
Morita, Aryan
Padamati, Sandeep Kumar
Schirhagl, Romana
Following Polymer Degradation with Nanodiamond Magnetometry
description Degradable polymers are widely used in the biomedical fields due to non-toxicity and great biocompatibility and biodegradability, and it is crucial to understand how they degrade. These polymers are exposed to various biochemical media in medical practice. Hence, it is important to precisely follow the degradation of the polymer in real time. In this study, we made use of diamond magnetometry for the first time to track polymer degradation with nanoscale precision. The method is based on a fluorescent defect in nanodiamonds, which changes its optical properties based on its magnetic surrounding. Since optical signals can be read out more sensitively than magnetic signals, this method allows unprecedented sensitivity. We used a specific mode of diamond magnetometry called relaxometry or T1 measurements. These are sensitive to magnetic noise and thus can detect paramagnetic species (gadolinium in this case). Nanodiamonds were incorporated into polylactic acid (PLA) films and PLA nanoparticles in order to follow polymer degradation. However, in principle, they can be incorporated into other polymers too. We found that T1 constants decreased gradually with the erosion of the film exposed to an alkaline condition. In addition, the mobility of nanodiamonds increased, which allows us to estimate polymer viscosity. The degradation rates obtained using this approach were in good agreement with data obtained by quartz crystal microbalance, Fourier-transform infrared spectroscopy, and atomic force microscopy.
format Article
PeerReviewed
author Li, Runrun
Vedelaar, Thea
Mzyk, Aldona
Morita, Aryan
Padamati, Sandeep Kumar
Schirhagl, Romana
author_facet Li, Runrun
Vedelaar, Thea
Mzyk, Aldona
Morita, Aryan
Padamati, Sandeep Kumar
Schirhagl, Romana
author_sort Li, Runrun
title Following Polymer Degradation with Nanodiamond Magnetometry
title_short Following Polymer Degradation with Nanodiamond Magnetometry
title_full Following Polymer Degradation with Nanodiamond Magnetometry
title_fullStr Following Polymer Degradation with Nanodiamond Magnetometry
title_full_unstemmed Following Polymer Degradation with Nanodiamond Magnetometry
title_sort following polymer degradation with nanodiamond magnetometry
publisher American Chemical Society
publishDate 2022
url https://repository.ugm.ac.id/282743/1/Morita_KG.pdf
https://repository.ugm.ac.id/282743/
https://pubs.acs.org/doi/10.1021/acssensors.1c01782
https://doi.org/10.1021/acssensors.1c01782
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