Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib

Purpose: This study implements a physiologically based pharmacokinetic (PBPK) modelling approach to predict the effect of hydrastine and berberine, two major alkaloids present in goldenseal extract, on pharmacokinetics of imatinib and bosutinib. Methods: PBPK models of hydrastine and berberine were...

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Bibliographic Details
Main Authors: Adiwidjaja, Jeffry, Boddy, Alan V., McLachlan, Andrew J.
Format: Article PeerReviewed
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2022
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Online Access:https://repository.ugm.ac.id/283068/1/Physiologically%20based%20pharmacokinetic%20model%20predictions%20of%20natural%20product-drug%20interactions%20between%20goldenseal%2C%20berberine%2C%20imatinib%20and%20bosutinib.pdf
https://repository.ugm.ac.id/283068/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123083703&doi=10.1007%2fs00228-021-03266-y&partnerID=40&md5=80ba99ea75d46cb5070d02a79635dcec
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Institution: Universitas Gadjah Mada
Language: English