Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers

Objective: This study aimed to investigate the association of sTILs with clinicopathological parameters and overall survival (OS) in patients with triple negative breast cancer (TNBC). Methods: One hundred and twenty-five paraffin embedded tissue of patients with TNBC, collected from Dr. Sardjito Ge...

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Main Authors: Widodo, Irianiwati, Ghozali, Ahmad, Purwanto, Ibnu, Ferronika, Paranita
Format: Article PeerReviewed
Language:English
Published: Asian Pacific Organization for Cancer Prevention 2022
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Online Access:https://repository.ugm.ac.id/283167/1/19.pdf
https://repository.ugm.ac.id/283167/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85136856851&doi=10.31557%2fAPJCP.2022.23.8.2749&partnerID=40&md5=b851e0540214a54906ef608f4b547fda
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spelling id-ugm-repo.2831672023-11-20T01:52:23Z https://repository.ugm.ac.id/283167/ Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers Widodo, Irianiwati Ghozali, Ahmad Purwanto, Ibnu Ferronika, Paranita Cancer Diagnosis Objective: This study aimed to investigate the association of sTILs with clinicopathological parameters and overall survival (OS) in patients with triple negative breast cancer (TNBC). Methods: One hundred and twenty-five paraffin embedded tissue of patients with TNBC, collected from Dr. Sardjito General Hospital Yogyakarta, Indonesia, between 2008-2017, were used in this study. Stromal TILs were examined from hematoxylin and eosin (H&E)-stained samples, and classified as either low or high score using 20 cut-off. Analysis of the association of sTILs with clinicopathological parameters, relative risk (RR) and OS used 95 confidence interval (CI) with significance set as p<0.05. Results: The higher proportion of TNBC patients in this study were ≥40 years old (83.3), high tumor grade (68), tumor stage >IIIa (56), alive (50.4), and with low sTILs (54.4). The results showed significant association between sTILs and a higher grade or a lower stage of tumor (B = 0.259, 95CI = 0.090-0.468, p = 0.004 and B = -0.255, 95CI = -0.433 - -0.080, p = 0.005, respectively ). Meanwhile sTILs were not associated with age at diagnosis (B = 0.027, 95CI = -0.193 – 0.264 p = 0.758 nor 3-year OS of patients (HR = 0.342, 95CI = 0.41 - 1.43 p = 0.402). Conclusion: The results indicate that sTILs may serve as an additional pathological parameter for TNBC. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License Asian Pacific Organization for Cancer Prevention 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283167/1/19.pdf Widodo, Irianiwati and Ghozali, Ahmad and Purwanto, Ibnu and Ferronika, Paranita (2022) Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers. Asian Pacific Journal of Cancer Prevention, 23 (8). 2749 -2754. ISSN 2476-762X https://www.scopus.com/inward/record.uri?eid=2-s2.0-85136856851&doi=10.31557%2fAPJCP.2022.23.8.2749&partnerID=40&md5=b851e0540214a54906ef608f4b547fda 10.31557/APJCP.2022.23.8.2749
institution Universitas Gadjah Mada
building UGM Library
continent Asia
country Indonesia
Indonesia
content_provider UGM Library
collection Repository Civitas UGM
language English
topic Cancer Diagnosis
spellingShingle Cancer Diagnosis
Widodo, Irianiwati
Ghozali, Ahmad
Purwanto, Ibnu
Ferronika, Paranita
Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
description Objective: This study aimed to investigate the association of sTILs with clinicopathological parameters and overall survival (OS) in patients with triple negative breast cancer (TNBC). Methods: One hundred and twenty-five paraffin embedded tissue of patients with TNBC, collected from Dr. Sardjito General Hospital Yogyakarta, Indonesia, between 2008-2017, were used in this study. Stromal TILs were examined from hematoxylin and eosin (H&E)-stained samples, and classified as either low or high score using 20 cut-off. Analysis of the association of sTILs with clinicopathological parameters, relative risk (RR) and OS used 95 confidence interval (CI) with significance set as p<0.05. Results: The higher proportion of TNBC patients in this study were ≥40 years old (83.3), high tumor grade (68), tumor stage >IIIa (56), alive (50.4), and with low sTILs (54.4). The results showed significant association between sTILs and a higher grade or a lower stage of tumor (B = 0.259, 95CI = 0.090-0.468, p = 0.004 and B = -0.255, 95CI = -0.433 - -0.080, p = 0.005, respectively ). Meanwhile sTILs were not associated with age at diagnosis (B = 0.027, 95CI = -0.193 – 0.264 p = 0.758 nor 3-year OS of patients (HR = 0.342, 95CI = 0.41 - 1.43 p = 0.402). Conclusion: The results indicate that sTILs may serve as an additional pathological parameter for TNBC. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License
format Article
PeerReviewed
author Widodo, Irianiwati
Ghozali, Ahmad
Purwanto, Ibnu
Ferronika, Paranita
author_facet Widodo, Irianiwati
Ghozali, Ahmad
Purwanto, Ibnu
Ferronika, Paranita
author_sort Widodo, Irianiwati
title Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
title_short Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
title_full Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
title_fullStr Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
title_full_unstemmed Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers
title_sort stromal tumor infiltrating lymphocytes (stils) were associated with a higher grade and a lower stage of indonesian triple negative breast cancers
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2022
url https://repository.ugm.ac.id/283167/1/19.pdf
https://repository.ugm.ac.id/283167/
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85136856851&doi=10.31557%2fAPJCP.2022.23.8.2749&partnerID=40&md5=b851e0540214a54906ef608f4b547fda
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