The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response

The influence of metformin transporter gene SLC22A1 and SLC47A1 variants on steady-state pharmacokinetics and glycemic response

Interindividual variation is important in the response to metformin as the first-line therapy for type-2 diabetes mellitus (T2DM). Considering that OCT1 and MATE1 transporters determine the metformin pharmacokinetics, this study aimed to investigate the influence of SLC22A1 and SLC47A1 variants on t...

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Main Authors: Ningrum, Vitarani Dwi Ananda, Sadewa, Ahmad Hamim, Ikawati, Zullies, Yuliwulandari, Rika, Ikhsan, M. Robikhul, Fajriyah, Rohmatul
Format: Article PeerReviewed
Language:English
Published: Public Library of Science 2022
Subjects:
Pharmacology and Pharmaceutical Sciences
Online Access:https://repository.ugm.ac.id/283574/1/Vitarani%20Dwi%20Ananda%20Ningrum_The%20influence%20of%20metformin.pdf
https://repository.ugm.ac.id/283574/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271410
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Institution: Universitas Gadjah Mada
Language: English

Internet

https://repository.ugm.ac.id/283574/1/Vitarani%20Dwi%20Ananda%20Ningrum_The%20influence%20of%20metformin.pdf
https://repository.ugm.ac.id/283574/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0271410

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