Population Pharmacokinetic Modelling and Limited Sampling Strategies for Therapeutic Drug Monitoring of Pyrazinamide in Patients with Tuberculosis

• Main Authors: Abolhassani-Chimeh, Reihaneh, Akkerman, Onno W., Saktiawati, Antonia M. I., Punt, Nieko C., Bolhuis, Mathieu S., Subronto, Yanri Wijayant, Sumardi, Sumardi, van der Werf, Tjip S., Kosterink, Jos G. W., Alffenaar, Jan-Willem C., Sturkenboom, Marieke G. G.
• Format: Article PeerReviewed
• Language: English
• Published: American Society for Microbiology 2022
• Subjects: Medical Microbiology; Clinical Pharmacology and Therapeutics
• Online Access: https://repository.ugm.ac.id/283630/1/Add_Abolhassani-Chimeh_Population%20pharmacokinetic.pdf; https://repository.ugm.ac.id/283630/; https://journals.asm.org/doi/full/10.1128/aac.00003-22
• Institution: Universitas Gadjah Mada

Pyrazinamide is one of the first-line antituberculosis drugs. The efficacy of pyrazinamide is associated with the ratio of 24-h area under the concentration–time curve (AUC24) to MIC. The objective of this study was to develop and validate a limited sampling strategy (LSS) based on a population phar...