Preparation of Citric Acid-Locust Bean Gum (CA-LBG) for the Disintegrating Agent of Tablet Dosage Forms
Purpose: Analyze the effect of HCl concentration 0.24 mol as a synthesis catalyst on the viscosity of CA-LBG and determine the effect of the application of CA-LBG as a disintegrating agent on the physical quality of tablets. Methods: Citric acid-locust bean gum (CA-LBG) was synthesized from citric a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article PeerReviewed |
| Language: | English |
| Published: |
Springer
2022
|
| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/283677/1/Preparation%20of%20Citric%20Acid-Locust%20Bean%20Gum%20%28CA-LBG%29%20for%20the%20Disintegrating%20Agent%20of%20Tablet%20Dosage%20Forms.pdf https://repository.ugm.ac.id/283677/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116873377&doi=10.1007%2fs12247-021-09591-0&partnerID=40&md5=13093a001a433dc054918f27d0c026b4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Gadjah Mada |
| Language: | English |
| Summary: | Purpose: Analyze the effect of HCl concentration 0.24 mol as a synthesis catalyst on the viscosity of CA-LBG and determine the effect of the application of CA-LBG as a disintegrating agent on the physical quality of tablets. Methods: Citric acid-locust bean gum (CA-LBG) was synthesized from citric acid (CA) and locust bean gum (LBG) using hydrochloric acid (HCl) and ultraviolet irradiation (UV 254 nm, 100 min). The CA-LBG was analyzed by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), scanning electron microscopy (SEM), esterification efficiency, solubility, and viscosity. The tablet formulation used CA-LBG with a concentration variation of 0.5, 1, 2, 4, 8, and 12. Preparation of tablets by direct compression uses a spray dray lactose (SDL) as a filler with a tablet weight of 200 mg. Results: Synthesis conditions using 0.24 mol HCl to produce CA-LBG 9.48 cP. The presence of CA-LBG as a disintegrating agent has variation effects to thickness, break force, tensile strength, and friability according to the concentration used. In the formulation process, increasing the concentration of CA-LBG in the tablet mass decreased the flow rate and increased compressibility. Conclusion: The increase in the concentration of CA-LBG in tablets accelerated the disintegration of tablets without the influence of other tablet parameters. The CA-LBG disintegration activity through repulsion between CA-LBG deformations on the tablet when wetted with disintegration medium. The repulsion force occurs due to the character of CA-LBG which has low solubility and low viscosity. Graphical Abstract: Figure not available: see fulltext. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
|---|