Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges
Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship b...
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Revista Brasileira de Farmacognosia
2022
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Online Access: | https://repository.ugm.ac.id/283932/1/StructureActivity-Relationship-of-Cytotoxic-Natural-Products-from-Indonesian-Marine-SpongesRevista-Brasileira-de-Farmacognosia.pdf https://repository.ugm.ac.id/283932/ https://link.springer.com/article/10.1007/s43450-021-00195-w https://doi.org/10.1007/s43450-021-00195-w |
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id-ugm-repo.2839322023-11-24T08:20:38Z https://repository.ugm.ac.id/283932/ Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges Panggabean, Jonathan A. Adiguna, Sya’ban P. Murniasih, Tutik Rahmawati, Siti I. Bayu, Asep Putra, Masteria Y. Organic Chemistry Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity. This review remarks the attempt to provide a preliminary guidance from the perspective of structure–activity relationship and its participation on marine natural products research. This guidance is segregated by the compound’s classes and their cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity. Structure–activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended to narrow down the endless possibilities of cytotoxicity by giving a predictable structure–activity relationship for active compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure–activity relationship with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge. Revista Brasileira de Farmacognosia 2022 Other NonPeerReviewed application/pdf en https://repository.ugm.ac.id/283932/1/StructureActivity-Relationship-of-Cytotoxic-Natural-Products-from-Indonesian-Marine-SpongesRevista-Brasileira-de-Farmacognosia.pdf Panggabean, Jonathan A. and Adiguna, Sya’ban P. and Murniasih, Tutik and Rahmawati, Siti I. and Bayu, Asep and Putra, Masteria Y. (2022) Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges. Revista Brasileira de Farmacognosia. https://link.springer.com/article/10.1007/s43450-021-00195-w https://doi.org/10.1007/s43450-021-00195-w |
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Organic Chemistry Panggabean, Jonathan A. Adiguna, Sya’ban P. Murniasih, Tutik Rahmawati, Siti I. Bayu, Asep Putra, Masteria Y. Structure–Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges |
description |
Indonesian marine natural products have been one of the most promising sources in the race to obtain potential drugs for
cancer treatment. One of the primary producers of cytotoxic compounds is sponges. However, there are still limited sources
of comprehensive reviews related to the relationship between the structure of isolated compounds and their cytotoxic activity.
This review remarks the attempt to provide a preliminary guidance from the perspective of structure–activity relationship
and its participation on marine natural products research. This guidance is segregated by the compound’s classes and their
cytotoxic targets to obtain and organized a reliable summary of inter-study of the isolated compounds and their cytotoxicity.
Structure–activity relationship is well-known for its ability to tune the bioactivity of a specific compound, especially on
synthetic organic chemistry and in silico study but rarely used on natural product chemistry. The present review is intended
to narrow down the endless possibilities of cytotoxicity by giving a predictable structure–activity relationship for active
compounds. In addition, bioactive framework leads were selected by uncovering a noticeable structure–activity relationship
with the intervention of cytotoxic agents from natural sources, especially Indonesian marine sponge. |
format |
Other NonPeerReviewed |
author |
Panggabean, Jonathan A. Adiguna, Sya’ban P. Murniasih, Tutik Rahmawati, Siti I. Bayu, Asep Putra, Masteria Y. |
author_facet |
Panggabean, Jonathan A. Adiguna, Sya’ban P. Murniasih, Tutik Rahmawati, Siti I. Bayu, Asep Putra, Masteria Y. |
author_sort |
Panggabean, Jonathan A. |
title |
Structure–Activity Relationship of Cytotoxic Natural Products
from Indonesian Marine Sponges |
title_short |
Structure–Activity Relationship of Cytotoxic Natural Products
from Indonesian Marine Sponges |
title_full |
Structure–Activity Relationship of Cytotoxic Natural Products
from Indonesian Marine Sponges |
title_fullStr |
Structure–Activity Relationship of Cytotoxic Natural Products
from Indonesian Marine Sponges |
title_full_unstemmed |
Structure–Activity Relationship of Cytotoxic Natural Products
from Indonesian Marine Sponges |
title_sort |
structure–activity relationship of cytotoxic natural products
from indonesian marine sponges |
publisher |
Revista Brasileira de Farmacognosia |
publishDate |
2022 |
url |
https://repository.ugm.ac.id/283932/1/StructureActivity-Relationship-of-Cytotoxic-Natural-Products-from-Indonesian-Marine-SpongesRevista-Brasileira-de-Farmacognosia.pdf https://repository.ugm.ac.id/283932/ https://link.springer.com/article/10.1007/s43450-021-00195-w https://doi.org/10.1007/s43450-021-00195-w |
_version_ |
1783956525786595328 |