The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review
Background: Cases of myocarditis development have been reported after administration of messenger ribonucleic acid (mRNA)-based coronavirus disease (COVID-19) vaccines. However, the reports vary among the studies, and the types of mRNA vaccines with potential to cause myocarditis remain unidentified...
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id-ugm-repo.2839472023-11-24T07:31:47Z https://repository.ugm.ac.id/283947/ The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review Rohman, M. Fajar, J. K. Soegiarto, G. Wulandari, L. Anshory, M. Ilmawan, M. Marlysawati, D. Purnamasari, Y. Kusuma, A. P. Asmiragani, A.. Adhiatma, D. Permanasari, A.E. Pasaribu, E. A. Maliga, H. A. Pamungkas, Y. Puteri, P. W. M. Sinaga, V. A. Setiawan, D. Putri, E. N. Fattima, E. T. Prawoto, O. L. Safitri, R. Yuliana, R. Hikmah, K. Putri, Y. S. Nurzaidah, L. Lianto, L. Cahya, M. D. Ikhsan, M. Ibrahim, I. Samudra, A. D. Tamara, F. Kartini, D. A. Mahendra, A. I. Dhama, K. Harapan, H. Medical Virology Background: Cases of myocarditis development have been reported after administration of messenger ribonucleic acid (mRNA)-based coronavirus disease (COVID-19) vaccines. However, the reports vary among the studies, and the types of mRNA vaccines with potential to cause myocarditis remain unidentified. The objective was to assess the cumulative prevalence of myocarditis and determine the association between myocarditis and mRNA-based COVID-19 vaccination. Methods: We performed a network meta-analysis by searching articles in PubMed, Scopus, and Web of Science. Information on the prevalence of myocarditis after the mRNA-based COVID-19 vaccination was collected from each study. Analysis was performed by calculating the pooled prevalence rate, and the association was determined using the Z-test. Data networking was performed using the Bayesian method. Results: A total of 18 papers was included in our analysis. We found that the cumulative prevalence of myocarditis was 1.7, 1.9, 1.2, and 1.1 per 100,000 population after vaccination with different types of mRNA-based COVID-19 vaccines, namely all mRNA COVID-19 vaccines, BNT162b1, mRNA-1273, and the combination of BNT162b1 and mRNA-1273, respectively. Moreover, the results revealed that BNT162b1 vaccination increased the risk of myocarditis by 1.64- and 1.71-folds compared to mRNA-1273 and the combination of BNT162b2 and mRNA-1273, respectively. Similar risks of developing myocarditis were observed after mRNA-1273 and the combination of BNT162b1 and mRNA-1273 vaccination. Conclusions: Our findings suggest the cumulative prevalence of myocarditis after mRNA-based COVID-19 vaccination with maximum prevalence was observed after BNT162b2 administration. BNT162b2 was associated with a higher risk of developing myocarditis than the other mRNA-based COVID-19 vaccines. F1000Research 2022 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/283947/1/35.pdf Rohman, M. and Fajar, J. K. and Soegiarto, G. and Wulandari, L. and Anshory, M. and Ilmawan, M. and Marlysawati, D. and Purnamasari, Y. and Kusuma, A. P. and Asmiragani, A.. and Adhiatma, D. and Permanasari, A.E. and Pasaribu, E. A. and Maliga, H. A. and Pamungkas, Y. and Puteri, P. W. M. and Sinaga, V. A. and Setiawan, D. and Putri, E. N. and Fattima, E. T. and Prawoto, O. L. and Safitri, R. and Yuliana, R. and Hikmah, K. and Putri, Y. S. and Nurzaidah, L. and Lianto, L. and Cahya, M. D. and Ikhsan, M. and Ibrahim, I. and Samudra, A. D. and Tamara, F. and Kartini, D. A. and Mahendra, A. I. and Dhama, K. and Harapan, H. (2022) The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review. F1000Research, 11 (862). ISSN 20461402 https://f1000research.com/articles/11-862 10.12688/f1000research.122139.1 |
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Medical Virology Rohman, M. Fajar, J. K. Soegiarto, G. Wulandari, L. Anshory, M. Ilmawan, M. Marlysawati, D. Purnamasari, Y. Kusuma, A. P. Asmiragani, A.. Adhiatma, D. Permanasari, A.E. Pasaribu, E. A. Maliga, H. A. Pamungkas, Y. Puteri, P. W. M. Sinaga, V. A. Setiawan, D. Putri, E. N. Fattima, E. T. Prawoto, O. L. Safitri, R. Yuliana, R. Hikmah, K. Putri, Y. S. Nurzaidah, L. Lianto, L. Cahya, M. D. Ikhsan, M. Ibrahim, I. Samudra, A. D. Tamara, F. Kartini, D. A. Mahendra, A. I. Dhama, K. Harapan, H. The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review |
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Background: Cases of myocarditis development have been reported after administration of messenger ribonucleic acid (mRNA)-based coronavirus disease (COVID-19) vaccines. However, the reports vary among the studies, and the types of mRNA vaccines with potential to cause myocarditis remain unidentified. The objective was to assess the cumulative prevalence of myocarditis and determine the association between myocarditis and mRNA-based COVID-19 vaccination.
Methods: We performed a network meta-analysis by searching articles in PubMed, Scopus, and Web of Science. Information on the prevalence of myocarditis after the mRNA-based COVID-19 vaccination was collected from each study. Analysis was performed by calculating the pooled prevalence rate, and the association was determined using the Z-test. Data networking was performed using the Bayesian method.
Results: A total of 18 papers was included in our analysis. We found that the cumulative prevalence of myocarditis was 1.7, 1.9, 1.2, and 1.1 per 100,000 population after vaccination with different types of mRNA-based COVID-19 vaccines, namely all mRNA COVID-19 vaccines, BNT162b1, mRNA-1273, and the combination of BNT162b1 and
mRNA-1273, respectively. Moreover, the results revealed that
BNT162b1 vaccination increased the risk of myocarditis by 1.64- and 1.71-folds compared to mRNA-1273 and the combination of BNT162b2 and mRNA-1273, respectively. Similar risks of developing myocarditis were observed after mRNA-1273 and the combination of BNT162b1
and mRNA-1273 vaccination. Conclusions: Our findings suggest the cumulative prevalence of myocarditis after mRNA-based COVID-19 vaccination with maximum prevalence was observed after BNT162b2 administration. BNT162b2 was associated with a higher risk of developing myocarditis than the
other mRNA-based COVID-19 vaccines. |
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Article PeerReviewed |
author |
Rohman, M. Fajar, J. K. Soegiarto, G. Wulandari, L. Anshory, M. Ilmawan, M. Marlysawati, D. Purnamasari, Y. Kusuma, A. P. Asmiragani, A.. Adhiatma, D. Permanasari, A.E. Pasaribu, E. A. Maliga, H. A. Pamungkas, Y. Puteri, P. W. M. Sinaga, V. A. Setiawan, D. Putri, E. N. Fattima, E. T. Prawoto, O. L. Safitri, R. Yuliana, R. Hikmah, K. Putri, Y. S. Nurzaidah, L. Lianto, L. Cahya, M. D. Ikhsan, M. Ibrahim, I. Samudra, A. D. Tamara, F. Kartini, D. A. Mahendra, A. I. Dhama, K. Harapan, H. |
author_facet |
Rohman, M. Fajar, J. K. Soegiarto, G. Wulandari, L. Anshory, M. Ilmawan, M. Marlysawati, D. Purnamasari, Y. Kusuma, A. P. Asmiragani, A.. Adhiatma, D. Permanasari, A.E. Pasaribu, E. A. Maliga, H. A. Pamungkas, Y. Puteri, P. W. M. Sinaga, V. A. Setiawan, D. Putri, E. N. Fattima, E. T. Prawoto, O. L. Safitri, R. Yuliana, R. Hikmah, K. Putri, Y. S. Nurzaidah, L. Lianto, L. Cahya, M. D. Ikhsan, M. Ibrahim, I. Samudra, A. D. Tamara, F. Kartini, D. A. Mahendra, A. I. Dhama, K. Harapan, H. |
author_sort |
Rohman, M. |
title |
The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review |
title_short |
The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review |
title_full |
The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review |
title_fullStr |
The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review |
title_full_unstemmed |
The global prevalence and association between the risk of myocarditis and mRNA-based COVID-19 vaccination: A network meta-analysis version 1; peer review: awaiting peer review |
title_sort |
global prevalence and association between the risk of myocarditis and mrna-based covid-19 vaccination: a network meta-analysis version 1; peer review: awaiting peer review |
publisher |
F1000Research |
publishDate |
2022 |
url |
https://repository.ugm.ac.id/283947/1/35.pdf https://repository.ugm.ac.id/283947/ https://f1000research.com/articles/11-862 |
_version_ |
1783956529052909568 |