Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma

• Main Authors: van de Pol, Jeroen A. A., Ferronika, Paranita, Westers, Helga, van Engeland, Manon, Terpstra, Martijn M., Smits, Kim M., de Lange, Kim, van den Brandt, Piet A., Sijmons, Rolf H., Schouten, Leo J., Kok, Klaas
• Format: Article PeerReviewed
• Language: English
• Published: Nature Research 2022
• Subjects: Clinical Sciences; Pathology
• Online Access: https://repository.ugm.ac.id/284277/1/Ferronika_KKMK.pdf; https://repository.ugm.ac.id/284277/; https://www.nature.com/articles/s41598-022-10455-x; https://doi.org/10.1038/s41598-022-10455-x
• Institution: Universitas Gadjah Mada

In this study, we investigate the influence of the seven genes (VHL, PBRM1, SETD2, BAP1, KDM5C, MTOR and TP53) most frequently mutated in clear cell renal cell cancer (ccRCC) on cancer-specific survival (CSS) in the prospective Netherlands Cohort Study on diet and cancer. DNA isolated from routinely...