Effect of Allicin for Re-epithelialization During Healing in Oral Ulcer Model

• Main Author: Perpustakaan UGM, i-lib
• Format: Article NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2011
• Subjects: Jurnal i-lib UGM
• Online Access: https://repository.ugm.ac.id/29088/; http://i-lib.ugm.ac.id/jurnal/download.php?dataId=12151
• Institution: Universitas Gadjah Mada

Allicin (diallyl thiosulfinate) isthe main component offresh garlic with multi-bioactivities astherapeutic agent. Recently,allicin is being proposed as alternative therapy for aphthous ulcer. The purpose of this study was to determine the effect of topical allicin in aqueous garlic extract on re-epithelialization during healing of acetic acid induced oral ulcer model. Thirty malesSDrats aged 2 months were equally divided into two groups as experimental and control groups. After sedated with 0.2 ml intramuscular Ketamine injection, ulcer model was made by applying 99.5% glacial acetic acid-moistened paper disc on rat buccal mucosa.This would generate an immediate necrotic tissue, which produced a single crateriform ulcer in each of the experimental rats for the next two days. In the experimental group, one drop of allicin was applied twice daily onto the lesion. Three rats in each group were sacrificed on days 2, 3, 6, 9 and 12 after induction and were recorded as H&#8320