PENGARUH SUPLEMENTASI KALSIUM KARBONAT DAN TERAPI INSULIN PADA INDUK TIKUS DIABETES MELLITUS TERHADAP ERUPSI GIGI DAN PERTUMBUHAN TULANG ALVEOLAR ANAK
Women with gestational Diabetes Mellitus experience a state of hyperglycemia, hormonal and metabolic changes, which can interfere with fetal development. These metabolism changes will affect the homeostasis of calcium, which may affect the bones and teeth of children born. Calcium carbonate has a hi...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2011
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/88558/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=50891 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Women with gestational Diabetes Mellitus experience a state of
hyperglycemia, hormonal and metabolic changes, which can interfere with fetal
development. These metabolism changes will affect the homeostasis of calcium,
which may affect the bones and teeth of children born. Calcium carbonate has a
high bioavailability that will produce high quality of bone and teeth. The aim of
this study was to examine the influence of calcium carbonate supplementation and
insulin therapy in diabetic rats on tooth eruption and alveolar bone growth of
offspring.
Twelve female Wistar rats, aged 3 months, weight 150-200 grams were
divided into 4 groups. Three rats were taken randomly as the control group. The
remaining nine rats were made diabetic by alloxan injection with the dosage of
170 mg/kg BW, further subdivided into 3 treatment groups. All rats were treated
gestation and then divided into group A of the control group, group B diabetic rats
with calcium supplementation, group C diabetic rats with calcium
supplementation and insulin therapy, and group D diabetic rats with insulin
therapy. The rat pups were sacrificed by decapitation at the age of 21 days, to
measure tooth eruption and alveolar bone growth. The measurement results were
analyzed using One-way Anova test and followed by LSD test.
The results showed tooth eruption and alveolar bone growth in diabetic
group with calcium supplementation and insulin therapy was greater than the
diabetic group with insulin therapy. The research conclusion was calcium
carbonate supplementation and insulin therapy in diabetic rats may reduce
interference of tooth eruption and alveolar bone growth of offspring. |
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